Literature DB >> 27913470

Role of the intestinal mucosa in acute gastrointestinal GVHD.

Jonathan U Peled1,2, Alan M Hanash1, Robert R Jenq1,2.   

Abstract

Intestinal graft-versus-host disease (GVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell transplantation. The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proximity with commensal microbes that reside within the intestinal lumen. Recent advances have significantly improved our understanding of the interactions between the intestinal mucosa and the enteric microbiota. Changes in host mucosal tissue and commensals posttransplant have been actively investigated, and provocative insights into mucosal immunity and the enteric microbiota are now being translated into clinical trials of novel approaches for preventing and treating acute GVHD. In this review, we summarize recent findings related to aspects of the intestinal mucosa during acute GVHD.
© 2016 by The American Society of Hematology. All rights reserved.

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Year:  2016        PMID： 27913470      PMCID： PMC5575743          DOI： 10.1182/asheducation-2016.1.119

Source DB:  PubMed          Journal:  Hematology Am Soc Hematol Educ Program        ISSN： 1520-4383


  125 in total

1.  Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine.

Authors:  Kwang Soon Kim; Sung-Wook Hong; Daehee Han; Jaeu Yi; Jisun Jung; Bo-Gie Yang; Jun Young Lee; Minji Lee; Charles D Surh
Journal:  Science       Date:  2016-01-28       Impact factor: 47.728

Review 2.  New developments in goblet cell mucus secretion and function.

Authors:  G M H Birchenough; M E V Johansson; J K Gustafsson; J H Bergström; G C Hansson
Journal:  Mucosal Immunol       Date:  2015-04-15       Impact factor: 7.313

3.  CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response.

Authors:  Brian C Betts; Elizabeth M Sagatys; Anandharaman Veerapathran; Mark C Lloyd; Francisca Beato; Harshani R Lawrence; Binglin Yue; Jongphil Kim; Said M Sebti; Claudio Anasetti; Joseph Pidala
Journal:  J Leukoc Biol       Date:  2015-02-06       Impact factor: 4.962

4.  MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.

Authors:  Caspar Ohnmacht; Joo-Hong Park; Sascha Cording; James B Wing; Koji Atarashi; Yuuki Obata; Valérie Gaboriau-Routhiau; Rute Marques; Sophie Dulauroy; Maria Fedoseeva; Meinrad Busslinger; Nadine Cerf-Bensussan; Ivo G Boneca; David Voehringer; Koji Hase; Kenya Honda; Shimon Sakaguchi; Gérard Eberl
Journal:  Science       Date:  2015-07-09       Impact factor: 47.728

Review 5.  Intestinal epithelial cells: regulators of barrier function and immune homeostasis.

Authors:  Lance W Peterson; David Artis
Journal:  Nat Rev Immunol       Date:  2014-03       Impact factor: 53.106

6.  Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection.

Authors:  Mousumi Mahapatro; Sebastian Foersch; Manuela Hefele; Gui-Wei He; Elisa Giner-Ventura; Tamar Mchedlidze; Markus Kindermann; Stefania Vetrano; Silvio Danese; Claudia Günther; Markus F Neurath; Stefan Wirtz; Christoph Becker
Journal:  Cell Rep       Date:  2016-05-12       Impact factor: 9.423

7.  The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.

Authors:  Dawn K Reichenbach; Vincent Schwarze; Benjamin M Matta; Victor Tkachev; Elisabeth Lieberknecht; Quan Liu; Brent H Koehn; Dietmar Pfeifer; Patricia A Taylor; Gabriele Prinz; Heide Dierbach; Natalie Stickel; Yvonne Beck; Max Warncke; Tobias Junt; Annette Schmitt-Graeff; Susumu Nakae; Marie Follo; Tobias Wertheimer; Lukas Schwab; Jason Devlin; Simon C Watkins; Justus Duyster; James L M Ferrara; Heth R Turnquist; Robert Zeiser; Bruce R Blazar
Journal:  Blood       Date:  2015-03-26       Impact factor: 22.113

Review 8.  Graft-versus-host disease.

Authors:  Warren D Shlomchik
Journal:  Nat Rev Immunol       Date:  2007-05       Impact factor: 53.106

9.  Importance and regulation of the colonic mucus barrier in a mouse model of colitis.

Authors:  J Petersson; O Schreiber; G C Hansson; S J Gendler; A Velcich; J O Lundberg; S Roos; L Holm; M Phillipson
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2010-11-25       Impact factor: 4.052

10.  Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD.

Authors:  Benjamin M Matta; Dawn K Reichenbach; Xiaoli Zhang; Lisa Mathews; Brent H Koehn; Gaelen K Dwyer; Jeremy M Lott; Franziska M Uhl; Dietmar Pfeifer; Colby J Feser; Michelle J Smith; Quan Liu; Robert Zeiser; Bruce R Blazar; Hēth R Turnquist
Journal:  Blood       Date:  2016-05-24       Impact factor: 22.113
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  2 in total

Review 1.  Clostridioides difficile Infection in the Stem Cell Transplant and Hematologic Malignancy Population.

Authors:  Elizabeth Ann Misch; Nasia Safdar
Journal:  Infect Dis Clin North Am       Date:  2019-06       Impact factor: 5.982

Review 2.  Innate lymphoid cells are double-edged swords under the mucosal barrier.

Authors:  Zhen Duan; Mandie Liu; Lin Yuan; Xizi Du; Mengping Wu; Yu Yang; Leyuan Wang; Kai Zhou; Ming Yang; Yizhou Zou; Yang Xiang; Xiangping Qu; Huijun Liu; Xiaoqun Qin; Chi Liu
Journal:  J Cell Mol Med       Date:  2021-08-10       Impact factor: 5.310
  2 in total

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