Min Li1, Hui Ming Yang2, Dong Xiao Luo3, Jian Zong Chen3, Heng Jun Shi4. 1. Institute o f Traditional Chinese Medicine, General Hospital of People s Liberation Army, Beijing 100853, China. Electronic address: kittenlee1115@126.com. 2. Institute o f Traditional Chinese Medicine, General Hospital of People s Liberation Army, Beijing 100853, China. 3. Department of Internal Medicine, Guang dong Provincial Hospital of Traditional Chinese Medicine, Guang zhou 510310, Guang dong Province, China. 4. Department of Traditional Chinese Medicine, Xijing Hospital, Forth Military Medical University, Xi an 710032, Shaanxi Provine, China.
Abstract
OBJECTIVES: To preliminarily assess the effects of Bushen Huoxue Granule (BHG) on Parkinson's Patients with Parkinson's Disease Questionnaire-39 (PDQ-39)and to provide data for further research. DESIGN: A randomized, double-blinded, placebo controlled study with a 3-month intervention period and a 6-month follow-up. INTERVENTIONS:Participants were patients with Parkinson's Disease (PD) of age ranging from 50 to 80 years and Hoehn and Yahr (H-Y) stage I-IV of the disease.120 participants were allocated to BHG group or placebo group at a 1:1 ratio. The BHG group received BHG twice a day for 3 months, and was followed-up for 6 months after treatment; the placebo group did not receive any Chinese Herb treatment for 9 months. All the patients were given the conventional therapy of levodopa (Madopar). MAIN OUTCOME MEASURES: Primary outcome measure was PDQ-39 comprises 39 questions with five different options of answer related to the frequency of the disease manifestation. RESULTS: Significant statistical difference appeared in the following PDQ-39 dimensions: mobility; emotional well-being; stigma; cognition (P<0.01) and bodily discomfort (P<0.05).There was no statistical difference in the dimensions of social support, ADL and communication between the data of these two group patients (P≥0.05). We found that the sum index of PDQ-39 was significantly different between two groups. CONCLUSION: The results of this study show that BHG treatment makes significant effects in most domains of PD patients life quality,especially in mobility, emotional well-being, stigma and cognition. The affected factors should be confirmed in larger studies. Copyright Â
RCT Entities:
OBJECTIVES: To preliminarily assess the effects of Bushen Huoxue Granule (BHG) on Parkinson'sPatients with Parkinson's Disease Questionnaire-39 (PDQ-39)and to provide data for further research. DESIGN: A randomized, double-blinded, placebo controlled study with a 3-month intervention period and a 6-month follow-up. INTERVENTIONS:Participants were patients with Parkinson's Disease (PD) of age ranging from 50 to 80 years and Hoehn and Yahr (H-Y) stage I-IV of the disease.120 participants were allocated to BHG group or placebo group at a 1:1 ratio. The BHG group received BHG twice a day for 3 months, and was followed-up for 6 months after treatment; the placebo group did not receive any Chinese Herb treatment for 9 months. All the patients were given the conventional therapy of levodopa (Madopar). MAIN OUTCOME MEASURES: Primary outcome measure was PDQ-39 comprises 39 questions with five different options of answer related to the frequency of the disease manifestation. RESULTS: Significant statistical difference appeared in the following PDQ-39 dimensions: mobility; emotional well-being; stigma; cognition (P<0.01) and bodily discomfort (P<0.05).There was no statistical difference in the dimensions of social support, ADL and communication between the data of these two group patients (P≥0.05). We found that the sum index of PDQ-39 was significantly different between two groups. CONCLUSION: The results of this study show that BHG treatment makes significant effects in most domains of PDpatients life quality,especially in mobility, emotional well-being, stigma and cognition. The affected factors should be confirmed in larger studies. Copyright Â
Authors: Sam Chun Sum Yuen; Ka Kit Chua; Linda L D Zhong; Kam Wa Chan; Conrad Kwan Ho Chan; Kam Leung Chan; Zhixiu Lin; Vincent Mok; Alexander Y Lau; Min Li Journal: Chin Med Date: 2022-01-24 Impact factor: 5.455