Literature DB >> 27912831

Systemic Treatment of Brain Metastases.

Saiama N Waqar1, Daniel Morgensztern2, Ramaswamy Govindan3.   

Abstract

Lung cancer continues to be the leading cause of cancer-related mortality in the United States. Brain metastases are a significant problem in patients with lung cancer and have conventionally been treated with whole-brain radiation. This article reviews the data for systemic chemotherapy to treat brain metastasis from lung cancer and examines the activity of small molecule tyrosine kinase inhibitors for the targeted therapy for brain metastases from EGFR-mutant and ALK-rearranged non-small cell lung cancer. Future directions for evaluating the role of immunotherapy in treating brain metastasis are also discussed. Copyright Â
© 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Brain metastases; Chemotherapy; Immunotherapy; Lung cancer; Targeted therapy

Mesh：

Substances：

Year:  2017        PMID： 27912831     DOI： 10.1016/j.hoc.2016.08.007

Source DB:  PubMed          Journal:  Hematol Oncol Clin North Am        ISSN： 0889-8588            Impact factor:   3.722


  5 in total

1.  A study on different therapies and prognosis-related factors for 101 patients with SCLC and brain metastases.

Authors:  Ying Liu; Xian-Hong Liu; Ying Wang; Jing Zhu; Ying Xin; Kai Niu; Sheng Wang; Ying Cheng
Journal:  Cancer Biol Ther       Date:  2017-08-16       Impact factor: 4.742

2.  Impact of PD-L1 expression, driver mutations and clinical characteristics on survival after anti-PD-1/PD-L1 immunotherapy versus chemotherapy in non-small-cell lung cancer: A meta-analysis of randomized trials.

Authors:  Qingyuan Huang; Hua Zhang; Josephine Hai; Mark A Socinski; Eric Lim; Haiquan Chen; Justin Stebbing
Journal:  Oncoimmunology       Date:  2018-06-20       Impact factor: 8.110

3.  Non-Small-Cell Lung Cancer With CNS Metastasis: Disparities From a Real-World Analysis (GBOT-LACOG 0417).

Authors:  Juliano Cé Coelho; Giselle de Souza Carvalho; Fabio Chaves; Pedro de Marchi; Gilberto de Castro; Clarissa Baldotto; Eldsamira Mascarenhas; Patricia Pacheco; Rafaela Gomes; Gustavo Werutsky; Luiz H Araujo
Journal:  JCO Glob Oncol       Date:  2022-03

Review 4.  Targeted drugs for systemic therapy of lung cancer with brain metastases.

Authors:  Ya-Wen Sun; Jian Xu; Jun Zhou; Wen-Juan Liu
Journal:  Oncotarget       Date:  2017-12-22

5.  Lung cancer with brain metastases remaining in continuous complete remission due to pembrolizumab and temozolomide: a case report.

Authors:  Xianmin Zhu; Shuang Dong; Jing Tang; Rong Xie; Huijing Wu; Paul Hofman; Maciej M Mrugala; Sheng Hu
Journal:  Ann Transl Med       Date:  2022-09
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.