| Literature DB >> 27912096 |
Javier Garcia-Bermudez1, Kivanç Birsoy2.
Abstract
In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of mitochondrial acetyl-coA acetyltransferase 1 (ACAT1). The authors further identify a small molecule ACAT1 inhibitor that displays anti-cancer effects. Copyright ÂEntities:
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Year: 2016 PMID： 27912096 DOI： 10.1016/j.molcel.2016.11.023
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970