| Literature DB >> 27912095 |
Scott A Foster1, Shiva Malek2.
Abstract
In this issue of Molecular Cell, Ritt et al. (2016) describe a stress-induced checkpoint that effectively suppresses RAS-MAPK signaling. This pathway, activated by agents such as Rigosertib that induce mitotic and oxidative stress, results in JNK-mediated inhibition of RAS-MAPK pathway components SOS and RAF. Copyright ÂEntities:
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Year: 2016 PMID： 27912095 DOI： 10.1016/j.molcel.2016.11.024
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970