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Literature DB >> 27911834

Profile of William Kaelin, Peter Ratcliffe, and Greg Semenza, 2016 Albert Lasker Basic Medical Research Awardees.

Randall S Johnson^1,2.

Abstract

Mesh：

Substances：

Year: 2016 PMID： 27911834 PMCID： PMC5150394 DOI： 10.1073/pnas.1617222113

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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17 in total

1. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Authors: P H Maxwell; M S Wiesener; G W Chang; S C Clifford; E C Vaux; M E Cockman; C C Wykoff; C W Pugh; E R Maher; P J Ratcliffe
Journal: Nature Date: 1999-05-20 Impact factor: 49.962

2. A conserved family of prolyl-4-hydroxylases that modify HIF.

Authors: R K Bruick; S L McKnight
Journal: Science Date: 2001-10-11 Impact factor: 47.728

3. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Authors: A C Epstein; J M Gleadle; L A McNeill; K S Hewitson; J O'Rourke; D R Mole; M Mukherji; E Metzen; M I Wilson; A Dhanda; Y M Tian; N Masson; D L Hamilton; P Jaakkola; R Barstead; J Hodgkin; P H Maxwell; C W Pugh; C J Schofield; P J Ratcliffe
Journal: Cell Date: 2001-10-05 Impact factor: 41.582

4. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Authors: P Jaakkola; D R Mole; Y M Tian; M I Wilson; J Gielbert; S J Gaskell; A von Kriegsheim; H F Hebestreit; M Mukherji; C J Schofield; P H Maxwell; C W Pugh; P J Ratcliffe
Journal: Science Date: 2001-04-05 Impact factor: 47.728

5. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

Authors: M Ivan; K Kondo; H Yang; W Kim; J Valiando; M Ohh; A Salic; J M Asara; W S Lane; W G Kaelin
Journal: Science Date: 2001-04-05 Impact factor: 47.728

6. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.

Authors: J B Hogenesch; W K Chan; V H Jackiw; R C Brown; Y Z Gu; M Pray-Grant; G H Perdew; C A Bradfield
Journal: J Biol Chem Date: 1997-03-28 Impact factor: 5.157

Profile of William Kaelin, Peter Ratcliffe, and Greg Semenza, 2016 Albert Lasker Basic Medical Research Awardees.

1. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

2. A conserved family of prolyl-4-hydroxylases that modify HIF.

3. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

4. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

5. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

6. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.

7. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.

8. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

Review 9. Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis.

10. Purification and characterization of hypoxia-inducible factor 1.

Review 1. The Chemical Biology of Ferroptosis in the Central Nervous System.