Merve Bicer1, Aslı Guler2, Gokcen Unal Kocabas3, Cetin Imamoglu4, Ali Baloglu5, Oktay Bilgir6, Arif Yuksel6, Giray Bozkaya7, Mehmet Calan3. 1. a Department of Obstetrics and Gynecology , Izmir University School of Medicine, Medical Park Hospital , Izmir , Turkey. 2. b Department of Family Physician , Izmir Bozyaka Training and Research Hospital , Izmir , Turkey. 3. c Department of Internal Medicine , Division of Endocrinology and Metabolism, Izmir Bozyaka Training and Research Hospital , Izmir , Turkey. 4. d Department of Radiology , Izmir Bozyaka Training and Research Hospital , Izmir , Turkey. 5. e Department of Obstetrics and Gynecology , Private Gynecology Clinic , Izmir , Turkey. 6. f Department of Internal Medicine , Izmir Bozyaka Training and Research Hospital , Izmir , Turkey. 7. g Department of Biochemistry and Clinical Biochemistry , Izmir Bozyaka Training and Research Hospital , Izmir , Turkey.
Abstract
PURPOSE: Endocan is a proteoglycan secreted mainly from endothelial cells. It has been implicated that there is a link between endocan and endothelial dysfunction. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disease associated with increased risk of cardiovascular events. The aims of this study were to ascertain whether circulating endocan levels are altered in women with PCOS, and whether there is an association between endocan and carotid intima media thickness (cIMT). MATERIALS AND METHODS: This cross-sectional study included 80 women with PCOS and 80 age- and BMI-matched controls without PCOS. Circulating endocan levels were measured using ELISA. Metabolic, hormonal parameters and cIMT were determined. 2-h oral glucose tolerance test (2-h OGTT) was performed on all women. RESULTS: Circulating endocan levels were significantly elevated in women with PCOS compared with controls (5.99 ± 2.37 vs. 3.66 ± 1.79 ng/ml, P < 0.001). Endocan levels positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free androgen index (FAI), high-sensitivity C-reactive protein (hs-CRP), and cIMT in both PCOS and control groups. Endocan levels did not correlate with fasting blood glucose, 2-h OGTT, A1C and lipid parameters. Multiple linear regression analysis revealed that endocan is an independent predictor for cIMT (β = 0.128, 95% CI = 0.118-0.138, P = 0.011). CONCLUSIONS: Circulating endocan levels are significantly higher in women with PCOS and endocan is independently associated with cIMT. Elevated endocan levels can be a predictor of increased cardiovascular risk in PCOS subjects.
PURPOSE:Endocan is a proteoglycan secreted mainly from endothelial cells. It has been implicated that there is a link between endocan and endothelial dysfunction. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disease associated with increased risk of cardiovascular events. The aims of this study were to ascertain whether circulating endocan levels are altered in women with PCOS, and whether there is an association between endocan and carotid intima media thickness (cIMT). MATERIALS AND METHODS: This cross-sectional study included 80 women with PCOS and 80 age- and BMI-matched controls without PCOS. Circulating endocan levels were measured using ELISA. Metabolic, hormonal parameters and cIMT were determined. 2-h oral glucose tolerance test (2-h OGTT) was performed on all women. RESULTS: Circulating endocan levels were significantly elevated in women with PCOS compared with controls (5.99 ± 2.37 vs. 3.66 ± 1.79 ng/ml, P < 0.001). Endocan levels positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free androgen index (FAI), high-sensitivity C-reactive protein (hs-CRP), and cIMT in both PCOS and control groups. Endocan levels did not correlate with fasting blood glucose, 2-h OGTT, A1C and lipid parameters. Multiple linear regression analysis revealed that endocan is an independent predictor for cIMT (β = 0.128, 95% CI = 0.118-0.138, P = 0.011). CONCLUSIONS: Circulating endocan levels are significantly higher in women with PCOS and endocan is independently associated with cIMT. Elevated endocan levels can be a predictor of increased cardiovascular risk in PCOS subjects.
Authors: Aleksandra Klisić; Nebojša Kavarić; Ludovico Abenavoli; Verica Stanišić; Vesna Spasojević-Kalimanovska; Jelena Kotur-Stevuljević; Ana Ninić Journal: J Med Biochem Date: 2020-09-02 Impact factor: 3.402
Authors: Aleksandra Klisić; Nebojša Kavarić; Vesna Spasojević-Kalimanovska; Jelena Kotur-Stevuljević; Ana Ninić Journal: J Med Biochem Date: 2021-01-26 Impact factor: 3.402