BACKGROUND: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. METHODS: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS = 11, non-DBS = 156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score. RESULTS: DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found. CONCLUSIONS: STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons.
BACKGROUND: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. METHODS: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS = 11, non-DBS = 156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score. RESULTS:DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found. CONCLUSIONS:STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons.
Authors: Gian Pal; Bichun Ouyang; Leo Verhagen; Geidy Serrano; Holly A Shill; Charles H Adler; Thomas G Beach; Jeffrey H Kordower Journal: Mov Disord Date: 2018-01-30 Impact factor: 10.338
Authors: Kathryn M Miller; Joseph R Patterson; Joseph Kochmanski; Christopher J Kemp; Anna C Stoll; Christopher U Onyekpe; Allyson Cole-Strauss; Kathy Steece-Collier; Jacob W Howe; Kelvin C Luk; Caryl E Sortwell Journal: J Neurosci Date: 2021-01-20 Impact factor: 6.167
Authors: Lisa Klingelhoefer; Björn H Falkenburger; Anika Frank; Jonas Bendig; Iñaki Schniewind; Witold H Polanski; Stephan B Sobottka; Heinz Reichmann; Katja Akgün; Tjalf Ziemssen Journal: Sci Rep Date: 2022-01-27 Impact factor: 4.379