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Literature DB >> 27910222

Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: A cross-comparison with migraine and healthy adults.

D-M Ellingsen^1,2, R G Garcia^1,3,4, J Lee¹, R L Lin¹, J Kim^1,5, A H Thurler⁶, S Castel⁶, L Dimisko⁶, B R Rosen¹, N Hadjikhani¹, B Kuo⁶, V Napadow¹.

Abstract

Cyclic Vomiting Syndrome (CVS) has been linked to episodic migraine, yet little is known about the precise brain-based mechanisms underpinning CVS, and whether these associated conditions share similar pathophysiology. We investigated the functional integrity of salience (SLN) and sensorimotor (SMN) intrinsic connectivity networks in CVS, migraine and healthy controls using brain functional Magnetic Resonance Imaging. CVS, relative to both migraine and controls, showed increased SLN connectivity to middle/posterior insula, a key brain region for nausea and viscerosensory processing. In contrast, this same region showed diminished SMN connectivity in both CVS and migraine. These results highlight both unique and potentially shared pathophysiology between these conditions, and suggest a potential target for therapeutics in future studies.

Entities: Chemical Disease Gene Species

Keywords: Cyclic Vomiting Syndrome; brain imaging; functional Magnetic Resonance; imaging; migraine

Mesh：

Year: 2016 PMID： 27910222 PMCID： PMC5423835 DOI： 10.1111/nmo.13004

Source DB: PubMed Journal: Neurogastroenterol Motil ISSN： 1350-1925 Impact factor: 3.598

22 in total

1. Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

Authors: Padhraig Gormley; Verneri Anttila; Bendik S Winsvold; Priit Palta; Tonu Esko; Tune H Pers; Kai-How Farh; Ester Cuenca-Leon; Mikko Muona; Nicholas A Furlotte; Tobias Kurth; Andres Ingason; George McMahon; Lannie Ligthart; Gisela M Terwindt; Mikko Kallela; Tobias M Freilinger; Caroline Ran; Scott G Gordon; Anine H Stam; Stacy Steinberg; Guntram Borck; Markku Koiranen; Lydia Quaye; Hieab H H Adams; Terho Lehtimäki; Antti-Pekka Sarin; Juho Wedenoja; David A Hinds; Julie E Buring; Markus Schürks; Paul M Ridker; Maria Gudlaug Hrafnsdottir; Hreinn Stefansson; Susan M Ring; Jouke-Jan Hottenga; Brenda W J H Penninx; Markus Färkkilä; Ville Artto; Mari Kaunisto; Salli Vepsäläinen; Rainer Malik; Andrew C Heath; Pamela A F Madden; Nicholas G Martin; Grant W Montgomery; Mitja I Kurki; Mart Kals; Reedik Mägi; Kalle Pärn; Eija Hämäläinen; Hailiang Huang; Andrea E Byrnes; Lude Franke; Jie Huang; Evie Stergiakouli; Phil H Lee; Cynthia Sandor; Caleb Webber; Zameel Cader; Bertram Muller-Myhsok; Stefan Schreiber; Thomas Meitinger; Johan G Eriksson; Veikko Salomaa; Kauko Heikkilä; Elizabeth Loehrer; Andre G Uitterlinden; Albert Hofman; Cornelia M van Duijn; Lynn Cherkas; Linda M Pedersen; Audun Stubhaug; Christopher S Nielsen; Minna Männikkö; Evelin Mihailov; Lili Milani; Hartmut Göbel; Ann-Louise Esserlind; Anne Francke Christensen; Thomas Folkmann Hansen; Thomas Werge; Jaakko Kaprio; Arpo J Aromaa; Olli Raitakari; M Arfan Ikram; Tim Spector; Marjo-Riitta Järvelin; Andres Metspalu; Christian Kubisch; David P Strachan; Michel D Ferrari; Andrea C Belin; Martin Dichgans; Maija Wessman; Arn M J M van den Maagdenberg; John-Anker Zwart; Dorret I Boomsma; George Davey Smith; Kari Stefansson; Nicholas Eriksson; Mark J Daly; Benjamin M Neale; Jes Olesen; Daniel I Chasman; Dale R Nyholt; Aarno Palotie
Journal: Nat Genet Date: 2016-09-28 Impact factor: 38.330

2. The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction.

Authors: Robert R Edwards; Vitaly Napadow; Jieun Kim; Marco L Loggia; Christine M Cahalan; Richard E Harris; Florian Beissner; Ronald G Garcia; Hyungjun Kim; Ajay D Wasan
Journal: Arthritis Rheumatol Date: 2015-05 Impact factor: 10.995

3. Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea.

Authors: Roberta Sclocco; Jieun Kim; Ronald G Garcia; James D Sheehan; Florian Beissner; Anna M Bianchi; Sergio Cerutti; Braden Kuo; Riccardo Barbieri; Vitaly Napadow
Journal: Cereb Cortex Date: 2014-08-12 Impact factor: 5.357

Review 4. The dynamic pain connectome.

Authors: Aaron Kucyi; Karen D Davis
Journal: Trends Neurosci Date: 2014-12-22 Impact factor: 13.837

5. Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome.

Authors: Kirsten Tillisch; Emeran A Mayer; Jennifer S Labus
Journal: Gastroenterology Date: 2010-08-07 Impact factor: 22.682

6. A comparison of dysautonomias comorbid with cyclic vomiting syndrome and with migraine.

Authors: Gisela Chelimsky; Shruti Madan; Amer Alshekhlee; Elizabeth Heller; Kevin McNeeley; Thomas Chelimsky
Journal: Gastroenterol Res Pract Date: 2010-01-06 Impact factor: 2.260

7. Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients.

Authors: Richard E Harris; Vitaly Napadow; John P Huggins; Lynne Pauer; Jieun Kim; Johnson Hampson; Pia C Sundgren; Bradley Foerster; Myria Petrou; Tobias Schmidt-Wilcke; Daniel J Clauw
Journal: Anesthesiology Date: 2013-12 Impact factor: 7.892

8. Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A.

Authors: R G Boles; E A Zaki; T Lavenbarg; R Hejazi; P Foran; J Freeborn; S Trilokekar; R McCallum
Journal: Neurogastroenterol Motil Date: 2009-04-08 Impact factor: 3.598

9. The missing link: enhanced functional connectivity between amygdala and visceroceptive cortex in migraine.

Authors: Nouchine Hadjikhani; Noreen Ward; Jasmine Boshyan; Vitaly Napadow; Yumi Maeda; Andrea Truini; Francesca Caramia; Emanuele Tinelli; Caterina Mainero
Journal: Cephalalgia Date: 2013-05-29 Impact factor: 6.292

10. Altered Brain Structure and Function Correlate with Disease Severity and Pain Catastrophizing in Migraine Patients.

Authors: Catherine S Hubbard; Shariq A Khan; Michael L Keaser; Vani A Mathur; Madhav Goyal; David A Seminowicz
Journal: eNeuro Date: 2014-12-30

9 in total

Review 1. Cyclic Vomiting Syndrome in Children and Adults: What Is New in 2018?

Authors: Katja Kovacic; Manu Sood; Thangam Venkatesan
Journal: Curr Gastroenterol Rep Date: 2018-08-29

Review 2. Cyclic Vomiting Syndrome in Children.

Authors: Anne Donnet; Sylvain Redon
Journal: Curr Pain Headache Rep Date: 2018-03-19

Review 3. Migraine, Cyclic Vomiting Syndrome, and Other Gastrointestinal Disorders.

Authors: Elliot S Yu; Yasodara Priyadharsini S S; Thangam Venkatesan
Journal: Curr Treat Options Gastroenterol Date: 2018-12

4. A picture is worth a thousand words: linking fibromyalgia pain widespreadness from digital pain drawings with pain catastrophizing and brain cross-network connectivity.

Authors: Dan-Mikael Ellingsen; Florian Beissner; Tawfik Moher Alsady; Asimina Lazaridou; Myrella Paschali; Michael Berry; Laura Isaro; Arvina Grahl; Jeungchan Lee; Ajay D Wasan; Robert R Edwards; Vitaly Napadow
Journal: Pain Date: 2021-05-01 Impact factor: 7.926

Review 5. Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions.

Authors: William L Hasler; David J Levinthal; Sally E Tarbell; Kathleen A Adams; B U K Li; Robert M Issenman; Irene Sarosiek; Safwan S Jaradeh; Ravi N Sharaf; Shahnaz Sultan; Thangam Venkatesan
Journal: Neurogastroenterol Motil Date: 2019-06 Impact factor: 3.598

6. Cyclic vomiting syndrome in children: a nationwide survey of current practice on behalf of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP).

Authors: Sara Isoldi; Giovanni Di Nardo; Saverio Mallardo; Pasquale Parisi; Umberto Raucci; Renato Tambucci; Paolo Quitadamo; Silvia Salvatore; Enrico Felici; Fabio Cisarò; Licia Pensabene; Claudia Banzato; Caterina Strisciuglio; Claudio Romano; Patrizia Fusco; Francesca Rigotti; Naire Sansotta; Silvia Caimmi; Salvatore Savasta; Giovanna Zuin; Marina Di Stefano; Silvia Provera; Angelo Campanozzi; Paolo Rossi; Simona Gatti; Mara Corpino; Patrizia Alvisi; Stefano Martelossi; Agnese Suppiej; Paolo Gandullia; Alberto Verrotti; Gianluca Terrin; Caterina Pacenza; Fabiola Fornaroli; Donatella Comito; Stefano D'Arrigo; Pasquale Striano; Federico Raviglione; Marco Carotenuto; Alessandro Orsini; Vincenzo Belcastro; Giovanna Di Corcia; Vincenzo Raieli; Michela Ada Noris Ferilli; Claudia Ruscitto; Elisabetta Spadoni; Salvatore Grosso; Renato D'Alonzo; Amanda Papa; Piero Pavone; Mariaclaudia Meli; Mario Velardita; Martina Mainetti; Nicola Vanacore; Osvaldo Borrelli
Journal: Ital J Pediatr Date: 2022-08-30 Impact factor: 3.288