| Literature DB >> 27909967 |
T L Zefirov1, L I Khisamieva2, N I Ziyatdinova2, A L Zefirov3.
Abstract
The study examined the dose-dependent effects of selective antagonists of α2A/D-, α2B-, and α2C- adrenoceptors applied in concentrations of 10-9-10-5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each α2-adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of α2A/D- and α2C-adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. α2B-Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles.Entities:
Keywords: chronotropy; heart; rat; α2-adrenoceptor
Mesh：
Substances：
Year: 2016 PMID： 27909967 DOI： 10.1007/s10517-016-3569-x
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804