Literature DB >> 27909960

Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus.

S V Michurina1,2, I Yu Ishchenko3,4, S A Arkhipov3,4, V V Klimontov3,4, L N Rachkovskaya3,4, V I Konenkov3,4, E L Zavyalov3,4.   

Abstract

The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels. Thee findings suggest a protective effect of the complex towards structural changes in the liver of mice with obesity and type 2 diabetes.

Entities:  

Keywords:  LYVE-1; liver; melatonin; sinusoidal cells; type 2 diabetes mellitus

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Substances：

Year:  2016        PMID： 27909960     DOI： 10.1007/s10517-016-3592-y

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  4 in total

1.  Effect of Melatonin on the Expression of LYVE-1 Receptor in Liver Sinusoidal Endothelial Cells of Mice with the Light-Induced Functional Pinealectomy Model.

Authors:  I Yu Ishchenko; S V Michurina; S A Arkhipov
Journal:  Bull Exp Biol Med       Date:  2022-06-23       Impact factor: 0.804

2.  Integrated bioinformatics analysis reveals novel key biomarkers and potential candidate small molecule drugs in gestational diabetes mellitus.

Authors:  Varun Alur; Varshita Raju; Basavaraj Vastrad; Anandkumar Tengli; Chanabasayya Vastrad; Shivakumar Kotturshetti
Journal:  Biosci Rep       Date:  2021-05-28       Impact factor: 3.840

Review 3.  Dietary Sources and Bioactivities of Melatonin.

Authors:  Xiao Meng; Ya Li; Sha Li; Yue Zhou; Ren-You Gan; Dong-Ping Xu; Hua-Bin Li
Journal:  Nutrients       Date:  2017-04-07       Impact factor: 5.717

4.  Investigation of candidate genes and mechanisms underlying obesity associated type 2 diabetes mellitus using bioinformatics analysis and screening of small drug molecules.

Authors:  G Prashanth; Basavaraj Vastrad; Anandkumar Tengli; Chanabasayya Vastrad; Iranna Kotturshetti
Journal:  BMC Endocr Disord       Date:  2021-04-26       Impact factor: 2.763
  4 in total

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