Literature DB >> 27909334

Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets.

Claes Wahlestedt1.   

Abstract

Mesh：

Year:  2017        PMID： 27909334      PMCID： PMC5143503          DOI： 10.1038/npp.2016.203

Source DB:  PubMed          Journal:  Neuropsychopharmacology        ISSN： 0893-133X            Impact factor:   7.853


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  6 in total

1.  The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.

Authors:  Chiara Pastori; Philipp Kapranov; Clara Penas; Veronica Peschansky; Claude-Henry Volmar; Jann N Sarkaria; Amade Bregy; Ricardo Komotar; Georges St Laurent; Nagi G Ayad; Claes Wahlestedt
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-25       Impact factor: 11.205

2.  Bromodomain inhibitors regulate the C9ORF72 locus in ALS.

Authors:  Zane Zeier; Rustam Esanov; Kinsley C Belle; Claude-Henry Volmar; Andrea L Johnstone; Paul Halley; Brooke A DeRosa; Nathalie Khoury; Marka van Blitterswijk; Rosa Rademakers; Jeffrey Albert; Shaun P Brothers; Joanne Wuu; Derek M Dykxhoorn; Michael Benatar; Claes Wahlestedt
Journal:  Exp Neurol       Date:  2015-06-20       Impact factor: 5.330

3.  Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice.

Authors:  Josefa M Sullivan; Ana Badimon; Uwe Schaefer; Pinar Ayata; James Gray; Chun-wa Chung; Melanie von Schimmelmann; Fan Zhang; Neil Garton; Nicholas Smithers; Huw Lewis; Alexander Tarakhovsky; Rab K Prinjha; Anne Schaefer
Journal:  J Exp Med       Date:  2015-09-21       Impact factor: 14.307

4.  Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.

Authors:  Gregory C Sartor; Samuel K Powell; Shaun P Brothers; Claes Wahlestedt
Journal:  J Neurosci       Date:  2015-11-11       Impact factor: 6.167

5.  BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.

Authors:  Erica Korb; Margo Herre; Ilana Zucker-Scharff; Robert B Darnell; C David Allis
Journal:  Nat Neurosci       Date:  2015-08-24       Impact factor: 24.884

6.  The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.

Authors:  Marco Magistri; Dmitry Velmeshev; Madina Makhmutova; Prutha Patel; Gregory C Sartor; Claude-Henry Volmar; Claes Wahlestedt; Mohammad Ali Faghihi
Journal:  Curr Alzheimer Res       Date:  2016       Impact factor: 3.498
  6 in total

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