Amish Jain1, Afif F El-Khuffash2, Bart C W Kuipers3, Adel Mohamed4, Kim A Connelly5, Patrick J McNamara6, Robert P Jankov7, Luc Mertens8. 1. Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Electronic address: ajain@mtsinai.on.ca. 2. Department of Neonatology, The Rotunda Hospital, Dublin, Ireland; Department of Pediatrics, The Royal College of Surgeons in Ireland, School of Medicine, Dublin, Ireland. 3. Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Pediatric Cardiology, Radboud UMC, Nijmegen, The Netherlands. 4. Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada. 5. Division of Neonatology, The Hospital for Sick Children, Toronto, Ontario, Canada; The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. 6. Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada. 7. Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada; The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada. 8. Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Heart and Stroke Richard Lewar Center of Excellence in Cardiovascular Research, Toronto, Canada.
Abstract
OBJECTIVES: To evaluate whether incorporating conventional, tissue Doppler imaging and speckle tracking echocardiography are reliable and can characterize changes in left ventricular (LV) function properly in healthy neonates in the early transitional newborn period. STUDY DESIGN: A prospective observational study was conducted in 50 healthy term neonates with a mean ± SD gestational age and birth weight of 39.3 ± 1.2 weeks and 3.5 ± 0.44 kg, respectively. All infants underwent serial echocardiograms at 15 ± 2 (day 1) and 35 ± 2 hours (day 2) of age. The LV dimensions and various functional indices including tissue Doppler imaging velocities and speckle tracking echocardiography-derived peak longitudinal strain, and systolic and diastolic strain rate were acquired and compared between time points. RESULTS: All measurements were feasible from each scan except speckle tracking echocardiography in 10% and 20% of images on days 1 and 2 of age, respectively. LV dimensions, but not functional measures, demonstrated a small to moderate positive correlation with birth weight. On day 2, a small reduction was observed in LV basal diameter, mitral valve inflow velocity time integral, and systolic velocity of the lateral wall and septum. Other indices remained unchanged. Tissue Doppler imaging-derived functional and flow-derived hemodynamic measures demonstrated the least measurement bias, and strain measurements demonstrated better reliability than strain rate, fractional shortening, and ejection fraction. CONCLUSION: The relative reliability of various echocardiographic indices to quantify LV function in neonates establish a normative dataset and provide evidence for their validity during the first 2 days of life.
OBJECTIVES: To evaluate whether incorporating conventional, tissue Doppler imaging and speckle tracking echocardiography are reliable and can characterize changes in left ventricular (LV) function properly in healthy neonates in the early transitional newborn period. STUDY DESIGN: A prospective observational study was conducted in 50 healthy term neonates with a mean ± SD gestational age and birth weight of 39.3 ± 1.2 weeks and 3.5 ± 0.44 kg, respectively. All infants underwent serial echocardiograms at 15 ± 2 (day 1) and 35 ± 2 hours (day 2) of age. The LV dimensions and various functional indices including tissue Doppler imaging velocities and speckle tracking echocardiography-derived peak longitudinal strain, and systolic and diastolic strain rate were acquired and compared between time points. RESULTS: All measurements were feasible from each scan except speckle tracking echocardiography in 10% and 20% of images on days 1 and 2 of age, respectively. LV dimensions, but not functional measures, demonstrated a small to moderate positive correlation with birth weight. On day 2, a small reduction was observed in LV basal diameter, mitral valve inflow velocity time integral, and systolic velocity of the lateral wall and septum. Other indices remained unchanged. Tissue Doppler imaging-derived functional and flow-derived hemodynamic measures demonstrated the least measurement bias, and strain measurements demonstrated better reliability than strain rate, fractional shortening, and ejection fraction. CONCLUSION: The relative reliability of various echocardiographic indices to quantify LV function in neonates establish a normative dataset and provide evidence for their validity during the first 2 days of life.
Authors: Aisling Smith; Jyothsna R Purna; Michael P Castaldo; Daniel Ibarra-Rios; Regan E Giesinger; Danielle R Rios; Dany E Weisz; Amish Jain; Afif F El-Khuffash; Patrick J McNamara Journal: Echocardiography Date: 2019-06-27 Impact factor: 1.724
Authors: Maria Jose Rodriguez; Jose Martinez-Orgado; Araceli Corredera; Irene Serrano; Luis Arruza Journal: Front Pediatr Date: 2022-05-25 Impact factor: 3.569
Authors: Deidra A Ansah; Benjamin E Reinking; Tarah T Colaizy; Robert D Roghair; Sarah E Haskell Journal: Neonatology Date: 2019-03-05 Impact factor: 4.035
Authors: Laura Thomas; Michelle Baczynski; Poorva Deshpande; Ashraf Kharrat; Sébastien Joye; Faith Zhu; Daniel Ibarra-Rios; Prakesh S Shah; Luc Mertens; Robert P Jankov; Xiang Y Ye; Elaine Neary; Joseph Ting; Michael Castaldo; Philip Levy; Aisling Smith; Afif F El-Khuffash; Regan E Giesinger; Patrick J McNamara; Dany E Weisz; Amish Jain Journal: BMJ Open Date: 2021-03-31 Impact factor: 2.692