Liyuan Han1, Yanfen Liu1, Changyi Wang2, Linlin Tang3, Xiaoqi Feng4, Thomas Astell-Burt4, Qi Wen2, Donghui Duan1, Nanjia Lu1, Guodong Xu1, Kaiyue Wang1, Lu Zhang1, Kaibo Gu1, Sihan Chen2, Jianping Ma2, Tao Zhang2, Dingyun You5, Shiwei Duan6. 1. School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, 315211, China. 2. Department of Chronic Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518054, China. 3. Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China. 4. Population Wellbeing and Environment Research Lab (PowerLab), Faculty of Social Sciences, University of Wollongong, NSW, 2522, Australia; Early Start Research Institute, Faculty of Social Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia. 5. Department of Science and Technology, Kunming Medical University, Kunming, 650500, China. Electronic address: youdingyun@qq.com. 6. School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, 315211, China. Electronic address: duanshiwei@nbu.edu.cn.
Abstract
AIMS: Hyperhomocysteinemia (HHcy) is known to increase the risk of many diseases. Factors influencing HHcy in healthy and hypertensive subjects remain under-researched. METHODS: A large population-based study was conducted in 60 communities from Shenzhen, China. Responses to standardized questions on lifestyle factors and blood samples were collected from all participants after a 12-h overnight fast. Multiple linear and multivariate logistic regressions were used to explore risk factors for HHcy. Results were then compared to those from a systematic review of English-language articles listed in Pubmed, EBSCOhost, Web of Science, Embase and Cochrane libraries that investigated HHcy risk factors in healthy and hypertensive subjects. RESULTS: A total of 1586 healthy (Male/Female = 642/944) and 5935 hypertensive subjects (Male/Female = 2928/3007) participated in our population-based study. In logistic regression analyses, age, BMI and creatinine (Cr) were risk factors, while being female, fruit intake and physical activity were protective factors for HHcy in healthy subjects. In hypertensive subjects, seven [age, smoking, salt intake, systolic blood pressure (SBP), uric acid, triglycerides (TG), and Cr] and four [female, fruit intake, total cholesterol (TC), and glucose] factors were associated with higher and lower HHcy respectively. The review of 71 studies revealed that potential risk factors for Hcy included nutritional, physiologic, lifestyle habits, ethnicity, genetics, interactions between gene-environment, gene-gene, gene-nutritional, environment-environment, nutritional-nutritional. CONCLUSION: Our study indicates the potential importance of increasing folic acid and vitamin B supplementation, daily fruit and vegetable intake, regular exercise and refraining from tobacco smoking and alcohol consumption as preventive strategies for Hcy.
AIMS: Hyperhomocysteinemia (HHcy) is known to increase the risk of many diseases. Factors influencing HHcy in healthy and hypertensive subjects remain under-researched. METHODS: A large population-based study was conducted in 60 communities from Shenzhen, China. Responses to standardized questions on lifestyle factors and blood samples were collected from all participants after a 12-h overnight fast. Multiple linear and multivariate logistic regressions were used to explore risk factors for HHcy. Results were then compared to those from a systematic review of English-language articles listed in Pubmed, EBSCOhost, Web of Science, Embase and Cochrane libraries that investigated HHcy risk factors in healthy and hypertensive subjects. RESULTS: A total of 1586 healthy (Male/Female = 642/944) and 5935 hypertensive subjects (Male/Female = 2928/3007) participated in our population-based study. In logistic regression analyses, age, BMI and creatinine (Cr) were risk factors, while being female, fruit intake and physical activity were protective factors for HHcy in healthy subjects. In hypertensive subjects, seven [age, smoking, salt intake, systolic blood pressure (SBP), uric acid, triglycerides (TG), and Cr] and four [female, fruit intake, total cholesterol (TC), and glucose] factors were associated with higher and lower HHcy respectively. The review of 71 studies revealed that potential risk factors for Hcy included nutritional, physiologic, lifestyle habits, ethnicity, genetics, interactions between gene-environment, gene-gene, gene-nutritional, environment-environment, nutritional-nutritional. CONCLUSION: Our study indicates the potential importance of increasing folic acid and vitamin B supplementation, daily fruit and vegetable intake, regular exercise and refraining from tobacco smoking and alcohol consumption as preventive strategies for Hcy.
Authors: Mohamed Haloul; Smita Jagdish Vinjamuri; Dina Naquiallah; Mohammed Imaduddin Mirza; Maryam Qureshi; Chandra Hassan; Mario Masrur; Francesco M Bianco; Patrice Frederick; Giulianotti P Cristoforo; Antonio Gangemi; Mohamed M Ali; Shane A Phillips; Abeer M Mahmoud Journal: Nutrients Date: 2020-07-07 Impact factor: 5.717
Authors: José Jonas de Oliveira; Alexandre de Souza E Silva; Anna Gabriela Silva Vilela Ribeiro; Carolina Gabriela Reis Barbosa; Jasiele Aparecida de Oliveira Silva; Annie Guimarães Pontes; João Paulo Estevam Batista; Adriana Pertille Journal: J Diabetes Metab Disord Date: 2021-02-22