Literature DB >> 27908273

Pharmacokinetic and Pharmacodynamic Features of Nanoemulsion Following Oral, Intravenous, Topical and Nasal Route.

Hira Choudhury1, Bapi Gorain2, Bappaditya Chatterjee3, Uttam K Mandal3, Pinaki Sengupta3, Rakesh K Tekade4.   

Abstract

BACKGROUND: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability, inconsistent absorption and inter/intra subject variability.
METHODS: Pharmaceutical emulsion holds a significant place as a primary choice of oral drug delivery system for lipophilic drugs used in pediatric and geriatric patients. Pharmacokinetic studies on nanoemulsion mediated drugs delivery approach indicates practical feasibility in regards to their clinical translation and commercialization.
RESULTS: This review article is to provide an updated understanding on pharmacokinetic and pharmacodynamic features of nanoemulsion delivered via oral, intravenous, topical and nasal route.
CONCLUSION: The article is of huge interest to formulation scientists working on range of lipophilic drug molecules intended to be administered through oral, intravenous, topical and nasal routes for vivid medical benefits. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Hydrophobicity; carbon nanotubes; oral delivery; pharmacodynamics; pharmacokinetics; routes of administration

Mesh：

Substances：

Year:  2017        PMID： 27908273     DOI： 10.2174/1381612822666161201143600

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  12 in total

Review 1.  Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends.

Authors:  Hira Choudhury; Manisha Pandey; Pei Xin Chin; Yee Lin Phang; Jeng Yuen Cheah; Shu Chien Ooi; Kit-Kay Mak; Mallikarjuna Rao Pichika; Prashant Kesharwani; Zahid Hussain; Bapi Gorain
Journal:  Drug Deliv Transl Res       Date:  2018-10       Impact factor: 4.617

2.  Hyaluronic acid-modified betamethasone encapsulated polymeric nanoparticles: fabrication, characterisation, in vitro release kinetics, and dermal targeting.

Authors:  Manisha Pandey; Hira Choudhury; Tarakini A P Gunasegaran; Saranyah Shanmugah Nathan; Shadab Md; Bapi Gorain; Minaketan Tripathy; Zahid Hussain
Journal:  Drug Deliv Transl Res       Date:  2019-04       Impact factor: 4.617

3.  Polymeric Microsphere Formulation for Colon Targeted Delivery of 5-Fluorouracil Using Biocompatible Natural Gum Katira.

Authors:  Saumen Karan; Hira Choudhury; Biplab Kumar Chakra; Tapan Kumar Chatterjee
Journal:  Asian Pac J Cancer Prev       Date:  2019-07-01

Review 4.  COVID-19 and cancer: From basic mechanisms to vaccine development using nanotechnology.

Authors:  Hyun Jee Han; Chinekwu Nwagwu; Obumneme Anyim; Chinedu Ekweremadu; San Kim
Journal:  Int Immunopharmacol       Date:  2020-12-02       Impact factor: 4.932

5.  Synthesis, Nanoformulations, and In Vitro Anticancer Activity of N-Substituted Side Chain Neocryptolepine Scaffolds.

Authors:  Ibrahim El-Tantawy El Sayed; Sami Ullah; Omar A Al-Hartomy; Asmaa Mohammed Hasanein; Abdullah A S Ahmed; Khaled A Kahilo; Mehrez E El-Naggar
Journal:  Molecules       Date:  2022-02-02       Impact factor: 4.411

6.  Tocotrienols-rich naringenin nanoemulgel for the management of diabetic wound: Fabrication, characterization and comparative in vitro evaluations.

Authors:  Eileen Yeo; Clement Jia Yew Chieng; Hira Choudhury; Manisha Pandey; Bapi Gorain
Journal:  Curr Res Pharmacol Drug Discov       Date:  2021-03-14

Review 7.  Mucoadhesive Nanocarriers as a Promising Strategy to Enhance Intracellular Delivery against Oral Cavity Carcinoma.

Authors:  Manisha Pandey; Hira Choudhury; Jenifer Ngu Shao Ying; Jessica Foo Sze Ling; Jong Ting; Jocelyn Su Szhiou Ting; Ivory Kuek Zhia Hwen; Ho Wan Suen; Hazimah Syazwani Samsul Kamar; Bapi Gorain; Neha Jain; Mohd Cairul Iqbal Mohd Amin
Journal:  Pharmaceutics       Date:  2022-04-05       Impact factor: 6.525

Review 8.  Nanocarrier Drug Delivery Systems: Characterization, Limitations, Future Perspectives and Implementation of Artificial Intelligence.

Authors:  Samar Zuhair Alshawwa; Abeer Ahmed Kassem; Ragwa Mohamed Farid; Shaimaa Khamis Mostafa; Gihan Salah Labib
Journal:  Pharmaceutics       Date:  2022-04-18       Impact factor: 6.525

Review 9.  Nanotechnology: an emerging approach to combat COVID-19.

Authors:  Anjani Devi Chintagunta; Sai Krishna M; Sanjana Nalluru; Sampath Kumar N S
Journal:  Emergent Mater       Date:  2021-02-15

Review 10.  Recent Progress in Lipid Nanoparticles for Cancer Theranostics: Opportunity and Challenges.

Authors:  Sarah I Bukhari; Syed Sarim Imam; Mohammad Zaki Ahmad; Parameswara Rao Vuddanda; Sultan Alshehri; Wael A Mahdi; Javed Ahmad
Journal:  Pharmaceutics       Date:  2021-06-07       Impact factor: 6.321
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