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Literature DB >> 27907816

Nucleic acid-sensing TLRs: trafficking and regulation.

Olivia Majer¹, Bo Liu¹, Gregory M Barton¹.

Abstract

Toll-like receptors (TLRs) play an important role in innate immune responses against pathogenic microorganisms or tissue damage. Nucleic acid (NA)-sensing TLRs localize in intracellular vesicular compartments and recognize foreign-derived and host-derived nucleic acid ligands. Inappropriate activation of NA-sensing TLRs can cause pathogenic inflammation and autoimmunity. Multiple regulatory mechanisms exist to limit recognition of self-NAs. This review summarizes recent progress that has been made in understanding how NA-sensing TLRs are regulated via trafficking, proteolytic cleavage, as well as ligand processing and recognition.

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Year: 2016 PMID： 27907816 PMCID： PMC5446938 DOI： 10.1016/j.coi.2016.10.003

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

63 in total

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Authors: Sarah E Ewald; Gregory M Barton
Journal: Curr Opin Immunol Date: 2010-12-14 Impact factor: 7.486

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Journal: J Immunol Date: 2011-12-14 Impact factor: 5.422

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42 in total

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Review 4. MicroRNAs in the Spinal Microglia Serve Critical Roles in Neuropathic Pain.

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5. Sequence Multiplicity within Spherical Nucleic Acids.

Authors: Ziyin N Huang; Lisa E Cole; Cassandra E Callmann; Shuya Wang; Chad A Mirkin
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6. Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection.

Authors: Luis H Franco; Anna K A Fleuri; Natália C Pellison; Gustavo F S Quirino; Catarina V Horta; Renan V H de Carvalho; Sérgio C Oliveira; Dario S Zamboni
Journal: J Biol Chem Date: 2017-06-12 Impact factor: 5.157

7. Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response.

Authors: Wei-Wei Li; Ying Nie; Yan Yang; Yong Ran; Wei-Wei Luo; Mei-Guang Xiong; Su-Yun Wang; Zhi-Sheng Xu; Yan-Yi Wang
Journal: Proc Natl Acad Sci U S A Date: 2020-09-02 Impact factor: 11.205