Literature DB >> 27906910

Progress with Scale-Up of HIV Viral Load Monitoring - Seven Sub-Saharan African Countries, January 2015-June 2016.

Shirley Lecher, Jason Williams, Peter N Fonjungo, Andrea A Kim, Dennis Ellenberger, Guoqing Zhang, Christiane Adje Toure, Simon Agolory, Georgette Appiah-Pippim, Suzanne Beard, Marie Yolande Borget, Sergio Carmona, Geoffrey Chipungu, Karidia Diallo, Marie Downer, Dianna Edgil, Holly Haberman, Mackenzie Hurlston, Steven Jadzak, Charles Kiyaga, William MacLeod, Boniface Makumb, Hellen Muttai, Christina Mwangi, Jane W Mwangi, Michael Mwasekaga, Mary Naluguza, Lucy W Ng'Ang'A, Shon Nguyen, Souleymane Sawadogo, Katrina Sleeman, Wendy Stevens, Joel Kuritsky, Shannon Hader, John Nkengasong.   

Abstract

The World Health Organization (WHO) recommends viral load testing as the preferred method for monitoring the clinical response of patients with human immunodeficiency virus (HIV) infection to antiretroviral therapy (ART) (1). Viral load monitoring of patients on ART helps ensure early diagnosis and confirmation of ART failure and enables clinicians to take an appropriate course of action for patient management. When viral suppression is achieved and maintained, HIV transmission is substantially decreased, as is HIV-associated morbidity and mortality (2). CDC and other U.S. government agencies and international partners are supporting multiple countries in sub-Saharan Africa to provide viral load testing of persons with HIV who are on ART. This report examines current capacity for viral load testing based on equipment provided by manufacturers and progress with viral load monitoring of patients on ART in seven sub-Saharan countries (Côte d'Ivoire, Kenya, Malawi, Namibia, South Africa, Tanzania, and Uganda) during January 2015-June 2016. By June 2016, based on the target numbers for viral load testing set by each country, adequate equipment capacity existed in all but one country. During 2015, two countries tested >85% of patients on ART (Namibia [91%] and South Africa [87%]); four countries tested <25% of patients on ART. In 2015, viral suppression was >80% among those patients who received a viral load test in all countries except Côte d'Ivoire. Sustained country commitment and a coordinated global effort is needed to reach the goal for viral load monitoring of all persons with HIV on ART.

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Year:  2016        PMID: 27906910     DOI: 10.15585/mmwr.mm6547a2

Source DB:  PubMed          Journal:  MMWR Morb Mortal Wkly Rep        ISSN: 0149-2195            Impact factor:   17.586


  57 in total

1.  Supporting Quality Data Systems: Lessons Learned from Early Implementation of Routine Viral Load Monitoring at a Large Clinic in Lilongwe, Malawi.

Authors:  Jean Gibb; Jimmy Chitsulo; Chifundo Chipungu; Mackenzie Chivwara; Alan Schooley; Risa M Hoffman
Journal:  J Clin Res HIV AIDS Prev       Date:  2017-03-14

2.  Rolling out HIV antiretroviral therapy in sub-Saharan Africa: 2003-2017.

Authors:  G Taylor
Journal:  Can Commun Dis Rep       Date:  2018-02-01

3.  Impact of Viral Load Monitoring on Retention and Viral Suppression: A Regression Discontinuity Analysis of South Africa's National Laboratory Cohort.

Authors:  Alyssa F Harlow; Jacob Bor; Alana T Brennan; Mhairi Maskew; William MacLeod; Sergio Carmona; Koleka Mlisana; Matthew P Fox
Journal:  Am J Epidemiol       Date:  2020-12-01       Impact factor: 4.897

4.  Access to HIV Viral Load Testing and Antiretroviral Therapy Switch Practices: A Multicountry Prospective Cohort Study in Sub-Saharan Africa.

Authors:  Pascale Ondoa; Andrea A Kim; T Sonia Boender; Guoqing Zhang; Stefanie Kroeze; Jeffrey Wiener; Tobias Rinke de Wit; John Nkengasong
Journal:  AIDS Res Hum Retroviruses       Date:  2020-08-27       Impact factor: 2.205

Review 5.  Point-of-Care HIV Viral Load Testing: an Essential Tool for a Sustainable Global HIV/AIDS Response.

Authors:  Paul K Drain; Jienchi Dorward; Andrew Bender; Lorraine Lillis; Francesco Marinucci; Jilian Sacks; Anna Bershteyn; David S Boyle; Jonathan D Posner; Nigel Garrett
Journal:  Clin Microbiol Rev       Date:  2019-05-15       Impact factor: 26.132

Review 6.  Diagnosis of Human Immunodeficiency Virus Infection.

Authors:  Bharat S Parekh; Chin-Yih Ou; Peter N Fonjungo; Mireille B Kalou; Erin Rottinghaus; Adrian Puren; Heather Alexander; Mackenzie Hurlston Cox; John N Nkengasong
Journal:  Clin Microbiol Rev       Date:  2018-11-28       Impact factor: 26.132

7.  Factors associated with recent unsuppressed viral load in HIV-1-infected patients in care on first-line antiretroviral therapy in South Africa.

Authors:  D Joseph Davey; Z Abrahams; M Feinberg; M Prins; C Serrao; B Medeossi; E Darkoh
Journal:  Int J STD AIDS       Date:  2018-01-16       Impact factor: 1.359

8.  Serum Albumin as a Prognostic Marker for Serious Non-AIDS Endpoints in the Strategic Timing of Antiretroviral Treatment (START) Study.

Authors:  Andreas Ronit; Shweta Sharma; Jason V Baker; Rosie Mngqibisa; Tristan Delory; Luis Caldeira; Nicaise Ndembi; Jens D Lundgren; Andrew N Phillips
Journal:  J Infect Dis       Date:  2018-01-17       Impact factor: 5.226

9.  Low Case Finding Among Men and Poor Viral Load Suppression Among Adolescents Are Impeding Namibia's Ability to Achieve UNAIDS 90-90-90 Targets.

Authors:  Simon Agolory; Michael de Klerk; Andrew L Baughman; Souleymane Sawadogo; Nicholus Mutenda; Ndumbu Pentikainen; Naemi Shoopala; Adam Wolkon; Negussie Taffa; Gram Mutandi; Anna Jonas; Assegid Tassew Mengistu; Edington Dzinotyiweyi; Dimitri Prybylski; Ndapewa Hamunime; Amy Medley
Journal:  Open Forum Infect Dis       Date:  2018-08-11       Impact factor: 3.835

10.  Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.

Authors: 
Journal:  Clin Infect Dis       Date:  2018-02-01       Impact factor: 9.079

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