| Literature DB >> 27905221 |
Paulin Mutwale Kapepula1,2, Patricia Mbombo Mungitshi2, Thierry Franck3, Ange Mouithys-Mickalad3, Dieudonné Mumba Ngoyi4,5, Pascal Dibungi T Kalenda2, Nadege Kabamba Ngombe2, Didier Serteyn3, Monique Tits1, Michel Frédérich1, Jean-Jacques Tamfum Muyembe4,5.
Abstract
The aim of this study was to evaluate and compare the cellular antioxidant activities of Lantana montevidensis, Lippia multiflora, and Ocimum gratissimum leaves often consumed as herbal teas in a rural area of Bandundu severely affected by konzo, which is related to oxidative damage. Consequently, dietary supplements with proven antioxidant potentialities could be of real interest to promote in this area. Phytochemical screening by TLC and HPLC-DAD of extracts revealed the presence of verbascoside as a major phenolic compound. Verbascoside in L. montevidensis and O. gratissimum is reported here for the first time. All extracts displayed high ABTS and DPPH radical-scavenging activities at the concentration range of 1-40 μg mL-1 according to order: L. multiflora > O. gratissimum > L. montevidensis. L. multiflora showed the best cellular antioxidant activity using DCFH-DA on HL-60 monocytes assay at 1-20 μg mL-1. These herbal teas may be used as nutraceuticals for their potent antioxidant activity.Entities:
Keywords: Congo D.R; Kahemba; Konzo; Lantana montevidensis; Lippia multiflora; Ocimum gratissimum; Oxidative stress
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Year: 2016 PMID: 27905221 PMCID: PMC5511081 DOI: 10.1080/14786419.2016.1263844
Source DB: PubMed Journal: Nat Prod Res ISSN: 1478-6419 Impact factor: 2.861