Literature DB >> 2790436

Trial of a novel experimental Toxoplasma iscom vaccine in pregnant sheep.

D Buxton, A Uggla, K Lövgren, K Thomson, A Lundén, B Morein, D A Blewett.   

Abstract

Fifteen vaccinated ewes (group 1) and 13 unvaccinated ewes (group 2) were each challenged orally with 2000 sporulated Toxoplasma gondii oocysts at 91 (+/- 1) days' gestation. Another four pregnant ewes acted as unvaccinated unchallenged controls. Lamb mortality in group 1 was 36.4% after a mean gestation of 141 days while in group 2 it was 64.7% after a mean gestation of 131.5 days. These differences were not statistically significant. However, substantially more specific antibody was detected in precolostral sera from live lambs from vaccinated ewes than in live lambs from unvaccinated ewes in group 2.

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Year:  1989        PMID: 2790436     DOI: 10.1016/0007-1935(89)90053-5

Source DB:  PubMed          Journal:  Br Vet J        ISSN: 0007-1935


  7 in total

1.  Molecular cloning, sequencing, and biological characterization of GRA4 gene of Toxoplasma gondii.

Authors:  Hira Ram; J R Rao; A K Tewari; P S Banerjee; A K Sharma
Journal:  Parasitol Res       Date:  2013-04-10       Impact factor: 2.289

2.  Immune responses and resistance to Toxoplasma gondii in mice immunized with antigens of the parasite incorporated into immunostimulating complexes.

Authors:  A Lundén; K Lövgren; A Uggla; F G Araujo
Journal:  Infect Immun       Date:  1993-06       Impact factor: 3.441

3.  Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene.

Authors:  H V Nielsen; S L Lauemøller; L Christiansen; S Buus; A Fomsgaard; E Petersen
Journal:  Infect Immun       Date:  1999-12       Impact factor: 3.441

Review 4.  Ovine toxoplasmosis: a review.

Authors:  D Buxton
Journal:  J R Soc Med       Date:  1990-08       Impact factor: 18.000

5.  Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep.

Authors:  Pablo Castaño; Miguel Fuertes; Ignacio Ferre; Miguel Fernández; Maria del Carmen Ferreras; Javier Moreno-Gonzalo; Camino González-Lanza; Frank Katzer; Javier Regidor-Cerrillo; Luis Miguel Ortega-Mora; Valentín Pérez; Julio Benavides
Journal:  Vet Res       Date:  2014-01-29       Impact factor: 3.683

Review 6.  A one health approach to vaccines against Toxoplasma gondii.

Authors:  Elisabeth A Innes; Clare Hamilton; Joao L Garcia; Andreas Chryssafidis; David Smith
Journal:  Food Waterborne Parasitol       Date:  2019-04-18

7.  Effective Nanoparticle-Based Nasal Vaccine Against Latent and Congenital Toxoplasmosis in Sheep.

Authors:  Céline Ducournau; Nathalie Moiré; Rodolphe Carpentier; Pauline Cantin; Clément Herkt; Isabelle Lantier; Didier Betbeder; Isabelle Dimier-Poisson
Journal:  Front Immunol       Date:  2020-09-09       Impact factor: 7.561

  7 in total

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