Literature DB >> 27902698

Correction: Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele.

Roy Ronen, Glenn Tesler, Ali Akbari, Shay Zakov, Noah A Rosenberg, Vineet Bafna.   

Abstract

[This corrects the article DOI: 10.1371/journal.pgen.1005527.].

Year:  2016        PMID: 27902698      PMCID: PMC5130173          DOI: 10.1371/journal.pgen.1006472

Source DB:  PubMed          Journal:  PLoS Genet        ISSN: 1553-7390            Impact factor:   5.917


In panel B of Fig 1, the two haplotypes on the right have incorrect scores of 17. The correct scores of these haplotypes are 18. Please view the correct Fig 1 here.
Fig 1

The HAF score.

Genealogies of three samples (n = 6) progressing through a selective sweep, from left to right. Neutral mutations are shown as red circles, and are numbered in red; the favored allele is shown as a red star. The 1-HAF score of each haplotype is shown below its corresponding leaf, in black. For the rightmost haplotype in (A), the binary haplotype vector h is shown along with its HAF-vector c, and 1-HAF and 2-HAF scores. Vector wall lists the frequencies of all mutations. (A) The favored allele appears on a single haplotype. At this point in time, both the genealogy and the HAF score distribution are largely neutral. Coalescence times (T2, …, T6) are shown on the left, where T spans the epoch with exactly k lineages. (B) Carriers of the favored allele are distinguished by high HAF scores (in large part due to the long branch of high-frequency hitchhiking variation); non-carriers have low HAF scores. (C) After fixation, there is a sharp loss of diversity causing low HAF scores across the sample.

The HAF score.

Genealogies of three samples (n = 6) progressing through a selective sweep, from left to right. Neutral mutations are shown as red circles, and are numbered in red; the favored allele is shown as a red star. The 1-HAF score of each haplotype is shown below its corresponding leaf, in black. For the rightmost haplotype in (A), the binary haplotype vector h is shown along with its HAF-vector c, and 1-HAF and 2-HAF scores. Vector wall lists the frequencies of all mutations. (A) The favored allele appears on a single haplotype. At this point in time, both the genealogy and the HAF score distribution are largely neutral. Coalescence times (T2, …, T6) are shown on the left, where T spans the epoch with exactly k lineages. (B) Carriers of the favored allele are distinguished by high HAF scores (in large part due to the long branch of high-frequency hitchhiking variation); non-carriers have low HAF scores. (C) After fixation, there is a sharp loss of diversity causing low HAF scores across the sample.
  1 in total

1.  Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele.

Authors:  Roy Ronen; Glenn Tesler; Ali Akbari; Shay Zakov; Noah A Rosenberg; Vineet Bafna
Journal:  PLoS Genet       Date:  2015-09-24       Impact factor: 5.917

  1 in total

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