| Literature DB >> 27902698 |
Roy Ronen, Glenn Tesler, Ali Akbari, Shay Zakov, Noah A Rosenberg, Vineet Bafna.
Abstract
[This corrects the article DOI: 10.1371/journal.pgen.1005527.].Year: 2016 PMID: 27902698 PMCID: PMC5130173 DOI: 10.1371/journal.pgen.1006472
Source DB: PubMed Journal: PLoS Genet ISSN: 1553-7390 Impact factor: 5.917
Fig 1The HAF score.
Genealogies of three samples (n = 6) progressing through a selective sweep, from left to right. Neutral mutations are shown as red circles, and are numbered in red; the favored allele is shown as a red star. The 1-HAF score of each haplotype is shown below its corresponding leaf, in black. For the rightmost haplotype in (A), the binary haplotype vector h is shown along with its HAF-vector c, and 1-HAF and 2-HAF scores. Vector wall lists the frequencies of all mutations. (A) The favored allele appears on a single haplotype. At this point in time, both the genealogy and the HAF score distribution are largely neutral. Coalescence times (T2, …, T6) are shown on the left, where T spans the epoch with exactly k lineages. (B) Carriers of the favored allele are distinguished by high HAF scores (in large part due to the long branch of high-frequency hitchhiking variation); non-carriers have low HAF scores. (C) After fixation, there is a sharp loss of diversity causing low HAF scores across the sample.