| Literature DB >> 27902331 |
Carolyne N Ngoi1,2, Juliana Siqueira2,3, Linlin Li2, Xutao Deng2, Peter Mugo1, Susan M Graham1,4, Matt A Price5,6, Eduard J Sanders1,7, Eric Delwart8,2.
Abstract
Viral nucleic acids present in the plasma of 498 Kenyan adults with unexplained fever were characterized by metagenomics analysis of 51 sample pools. The highest to lowest fraction of plasma pools was positive for parvovirus B19 (75 %), pegivirus C (GBV-C) (67 %), alpha anellovirus (59 %), gamma anellovirus (55 %), beta anellovirus (41 %), dengue virus genotype 2 (DENV-2) (16 %), human immunodeficiency virus type 1 (6 %), human herpesvirus 6 (6 %), HBV (4 %), rotavirus (4 %), hepatitis B virus (4 %), rhinovirus C (2 %), Merkel cell polyomavirus (MCPyV; 2 %) and Kadipiro virus (2 %). Ranking by overall percentage of viral reads yielded similar results. Characterization of viral nucleic acids in the plasma of a febrile East African population showed a high frequency of parvovirus B19 and DENV infections and detected a reovirus (Kadipiro virus) previously reported only in Asian Culex mosquitoes, providing a baseline to compare with future virome studies to detect emerging viruses in this region.Entities:
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Year: 2016 PMID： 27902331 PMCID： PMC5203674 DOI： 10.1099/jgv.0.000644
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891