Literature DB >> 279012

X-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma.

R R Weichselbaum, J Nove, J B Little.   

Abstract

Fibroblasts derived from patients with hereditary retinoblastoma appear to be more sensitive to the lethal effects of x-rays than do fibroblasts from patients with sporadic retinoblastoma or normal controls. A defect in DNA repair is postulated to account for the high incidence of second tumors in these patients. Retinoblastoma appears to be an interesting model for the study of genetic susceptibility to the development of spontaneous or radiation-induced tumors.

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Year:  1978        PMID： 279012      PMCID： PMC392909          DOI： 10.1073/pnas.75.8.3962

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Retinoblastoma and chromosome 13.

Authors:  U Francke
Journal:  Cytogenet Cell Genet       Date:  1976

2.  Chromosomal deletion and retinoblastoma.

Authors:  A G Knudson; A T Meadows; W W Nichols; R Hill
Journal:  N Engl J Med       Date:  1976-11-11       Impact factor: 91.245

3.  Skin fibroblasts from a D-deletion type retinoblastoma patient are abnormally X-ray sensitive.

Authors:  R R Weichselbaum; J Nove; J B Little
Journal:  Nature       Date:  1977-04-21       Impact factor: 49.962

4.  Pleiotropic effects of the gene for retinoblastoma.

Authors:  F D Kitchin; R M Ellsworth
Journal:  J Med Genet       Date:  1974-09       Impact factor: 6.318

5.  High-LET radiations induce a large proportion of non-rejoining DNA breaks.

Authors:  M A Ritter; J E Cleaver; C A Tobias
Journal:  Nature       Date:  1977-04-14       Impact factor: 49.962

6.  Sporadic bilateral retinoblastoma and 13q- chromosomal deletion.

Authors:  U Francke; F Kung
Journal:  Med Pediatr Oncol       Date:  1976

7.  Mutation theory of carcinogenesis in retinoblastoma.

Authors:  C Bonaïti-Pellie; M L Briard-Guillemot; J Feingold; J Frezal
Journal:  J Natl Cancer Inst       Date:  1976-08       Impact factor: 13.506

8.  In vitro radiosensitivity of human dipliod fibroblasts derived from patients with unusual clinical responses to radiation.

Authors:  R R Weichselbaum; J Epstein; J B Little
Journal:  Radiology       Date:  1976-11       Impact factor: 11.105

9.  Inherent cellular radiosensitivity of human tumors of varying clinical curability.

Authors:  R R Weichselbaum; J Epstein; J B Little; P Kornblith
Journal:  AJR Am J Roentgenol       Date:  1976-12       Impact factor: 3.959

10.  A new familial cancer syndrome? A spectrum of malignant and benign tumors including retinoblastoma, carcinoma of the bladder and other genitourinary tumors, thyroid adenoma, and a probable case of multifocal osteosarcoma.

Authors:  H Chan; C B Pratt
Journal:  J Natl Cancer Inst       Date:  1977-02       Impact factor: 13.506
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  6 in total

1.  Fibroblast radiosensitivity and intraocular fibrovascular proliferation following radiotherapy for bilateral retinoblastoma.

Authors:  D M Albert; D S Walton; R R Weichselbaum; J R Cassady; J B Little; D Leombruno; R Trantravahi; C A Puliafito
Journal:  Br J Ophthalmol       Date:  1986-05       Impact factor: 4.638

2.  Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair.

Authors:  J P Therrien; R Drouin; C Baril; E A Drobetsky
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

3.  Absence of chromosome breakage in patients with retinoblastoma.

Authors:  L A Knight; H A Gardner; B L Gallie
Journal:  Hum Genet       Date:  1979-09-02       Impact factor: 4.132

4.  Excess of cancer deaths in grandparents of patients with retinoblastoma.

Authors:  C Bonaïti-Pellié; M L Briard-Guillemot
Journal:  J Med Genet       Date:  1980-04       Impact factor: 6.318

5.  Cultured diploid fibroblasts from patients with the nevoid basal cell carcinoma syndrome are hypersensitive to killing by ionizing radiation.

Authors:  G L Chan; J B Little
Journal:  Am J Pathol       Date:  1983-04       Impact factor: 4.307

6.  Cell-culture studies on neurofibromatosis (von Recklinghausen's disease). III. Experiments on X-ray sensitivity.

Authors:  R Mao; W Krone; W Nothdurft; A Reisacher; H Gall
Journal:  Arch Dermatol Res       Date:  1985       Impact factor: 3.017
  6 in total

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