Rodica Cosgarea1, Simona Corina Senilă1, Radu Badea2, Loredana Ungureanu1. 1. Iuliu Hațieganu University of Medicine and Pharmacy, Department of Dermatology, Cluj-Napoca, Romania. 2. Ultrasonography Laboratory, Imaging and Radiology Department, "Octavian Fodor" Gastroenterology and Hepatology Regional Institute, Cluj-Napoca, Romania.
Abstract
BACKGROUND: Pyoderma gangrenosum is a rare, ulcerative, destructive, non-infectious dermatologic disease and it is one clinical entity within the spectrum of neutrophilic dermatoses. Visceral involvement, manifesting as sterile neutrophilic infiltrates in sites other than skin and, is infrequent. Splenic involvement is very rare. MAIN OBSERVATIONS: We present a case of a 58-year-old woman with pyoderma gangrenosum with spleen involvement and review all reports of similar cases.We have found nine reported cases, our case being the tenth. CONCLUSION: Our review showed that spleen involvement in the course of pyoderma gangrenosum can occur at any age. It is slightly more frequent in men. An underlying or associated neutrophilic disorder is present in almost half of the patients. Skin manifestations were usually present before splenic involvement. In most cases the disese responds well to glucocorticosteroids.
BACKGROUND:Pyoderma gangrenosum is a rare, ulcerative, destructive, non-infectious dermatologic disease and it is one clinical entity within the spectrum of neutrophilic dermatoses. Visceral involvement, manifesting as sterile neutrophilic infiltrates in sites other than skin and, is infrequent. Splenic involvement is very rare. MAIN OBSERVATIONS: We present a case of a 58-year-old woman with pyoderma gangrenosum with spleen involvement and review all reports of similar cases.We have found nine reported cases, our case being the tenth. CONCLUSION: Our review showed that spleen involvement in the course of pyoderma gangrenosum can occur at any age. It is slightly more frequent in men. An underlying or associated neutrophilic disorder is present in almost half of the patients. Skin manifestations were usually present before splenic involvement. In most cases the disese responds well to glucocorticosteroids.
Authors: A Dallot; J M Decazes; Y Drouault; M Rybojad; O Verola; P Morel; J Modai; A Puissant Journal: Br J Dermatol Date: 1988-12 Impact factor: 9.302
Authors: N Brahimi; E Maubec; O Boccara; E Marinho; L Valeyrie-Allanore; C Lecaille; V Sebban; B Hersent; C Picard-Dahan; V Descamps; B Crickx Journal: Ann Dermatol Venereol Date: 2008-12-09 Impact factor: 0.777