Sonja Kinner1, Tilman B Schubert2, Elisabetta A Nocerino3, Shannon Hynes4, Timothy J Colgan5, Agnes G Loeffler6, Christopher Brace5, Scott B Reeder7, Emily Winslow8. 1. Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany. Electronic address: SKinner@uwhealth.org. 2. Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA; Clinic of Radiology and Nuclear Medicine, Basel University Hospital, Basel, Switzerland. 3. Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA. 4. Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA. 5. Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA. 6. Pathology Clinic, University of Wisconsin-Madison, Madison, WI, USA. 7. Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, USA. 8. Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Abstract
PURPOSE: The detection of small parenchymal hepatic lesions identified by preoperative imaging remains a challenge for traditional pathologic methods in large specimens. We developed a magnetic resonance imaging (MRI) compatible localization device for imaging of surgical specimens aimed to improve identification and localization of hepatic lesions ex vivo. MATERIALS AND METHODS: The device consists of two stationary and one removable MR-visible grids lined with silicone gel, creating an orthogonal 3D matrix for lesion localization. To test the device, five specimens of swine liver with a random number of lesions created by microwave ablation were imaged on a 3T MR scanner. Two readers independently evaluated lesion coordinates and size, which were then correlated with sectioning guided by MR imaging. RESULTS: All lesions (n=38) were detected at/very close to the expected localization. Inter-reader agreement of lesion localization was almost perfect (0.92). The lesion size estimated by MRI matched macroscopic lesion size in cut specimen (±2mm) in 34 and 35, respectively, out of 38 lesions. CONCLUSION: Use of this MR compatible device for ex vivo imaging proved feasible for detection and three-dimensional localization of liver lesions, and has potential to play an important role in the ex vivo examination of surgical specimens in which pathologic correlation is clinically important. Copyright Â
PURPOSE: The detection of small parenchymal hepatic lesions identified by preoperative imaging remains a challenge for traditional pathologic methods in large specimens. We developed a magnetic resonance imaging (MRI) compatible localization device for imaging of surgical specimens aimed to improve identification and localization of hepatic lesions ex vivo. MATERIALS AND METHODS: The device consists of two stationary and one removable MR-visible grids lined with silicone gel, creating an orthogonal 3D matrix for lesion localization. To test the device, five specimens of swine liver with a random number of lesions created by microwave ablation were imaged on a 3T MR scanner. Two readers independently evaluated lesion coordinates and size, which were then correlated with sectioning guided by MR imaging. RESULTS: All lesions (n=38) were detected at/very close to the expected localization. Inter-reader agreement of lesion localization was almost perfect (0.92). The lesion size estimated by MRI matched macroscopic lesion size in cut specimen (±2mm) in 34 and 35, respectively, out of 38 lesions. CONCLUSION: Use of this MR compatible device for ex vivo imaging proved feasible for detection and three-dimensional localization of liver lesions, and has potential to play an important role in the ex vivo examination of surgical specimens in which pathologic correlation is clinically important. Copyright Â
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