Literature DB >> 27896944

Quantifying bias in survival estimates resulting from loss to follow-up among children with lymphoma in Malawi.

Christopher C Stanley1, Kate D Westmoreland1,2, Salama Itimu1, Ande Salima1, Toon van der Gronde1, Peter Wasswa3,4, Idah Mtete4, Mercy Butia4, Nader K El-Mallawany3, Satish Gopal1,2,5.   

Abstract

Pediatric lymphoma is common in sub-Saharan Africa, where survival estimates are often based on limited follow-up with incomplete retention, introducing potential for bias. We compared follow-up and overall survival (OS) between passive and active tracing within a prospective cohort of children with lymphoma in Malawi. Median follow-up times were 4.4 months (interquartile range [IQR] 2.0-9.4) and 10.8 months (IQR 6.2-20.6) in passive and active follow-up, respectively. Twelve-month overall survival (OS) was 69% (95% confidence interval [CI] 54-80) in passive and 44% (95% CI 34-54) in active follow-up. Passive follow-up significantly overestimated the OS and underestimated the mortality. Efforts to improve retention in regional studies are needed.
© 2016 Wiley Periodicals, Inc.

Entities:  

Keywords:  Malawi; loss to follow-up; lymphoma; pediatric cancer; sub-Saharan Africa

Mesh：

Year:  2016        PMID： 27896944      PMCID： PMC5520975          DOI： 10.1002/pbc.26370

Source DB:  PubMed          Journal:  Pediatr Blood Cancer        ISSN： 1545-5009            Impact factor:   3.167


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