Gustavo Deza1, Begoña García-Bravo2, Juan F Silvestre3, Maria A Pastor-Nieto4, Ricardo González-Pérez5, Felipe Heras-Mendaza6, Pedro Mercader7, Virginia Fernández-Redondo8, Bo Niklasson9, Ana M Giménez-Arnau1. 1. Department of Dermatology, Hospital del Mar, Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona (UAB), 08003 Barcelona, Spain. 2. Department of Dermatology, University Hospital Virgen Macarena, 41009 Sevilla, Spain. 3. Department of Dermatology, University Hospital of Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante- Fundación FISABIO, 03010 Alicante, Spain. 4. Department of Dermatology, University Hospital of Guadalajara, 19002 Guadalajara, Spain. 5. Department of Dermatology, University Hospital Araba, 01009 Vitoria, Spain. 6. Department of Dermatology, Fundación Jiménez Díaz, 28040 Madrid, Spain. 7. Department of Dermatology, University Hospital Morales Meseguer, 30008 Murcia, Spain. 8. Department of Dermatology, University Hospital Santiago de Compostela, 15706 Santiago de Compostela, Spain. 9. Chemotechnique Diagnostics, 235 39 Vellinge, Sweden.
Abstract
BACKGROUND: Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens. OBJECTIVES: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients. METHODS: Three different concentrations of Lim-OOHs (0.1%, 0.2% and 0.3% pet.) and Lin-OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain. RESULTS: Lim-OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin-OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5-1.9%) and doubtful reactions (0.4-0.5%) to both terpene hydroperoxides were registered at the highest concentrations tested. CONCLUSIONS: Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization.
BACKGROUND:Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens. OBJECTIVES: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients. METHODS: Three different concentrations of Lim-OOHs (0.1%, 0.2% and 0.3% pet.) and Lin-OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain. RESULTS:Lim-OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin-OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5-1.9%) and doubtful reactions (0.4-0.5%) to both terpene hydroperoxides were registered at the highest concentrations tested. CONCLUSIONS:Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization.
Authors: Gunnar S A Nyman; Ana Maria Giménez-Arnau; Jurate Grigaitiene; Laura Malinauskiene; Evy Paulsen; Lina Hagvall Journal: Acta Derm Venereol Date: 2021-11-11 Impact factor: 3.875