| Literature DB >> 27894871 |
Wenming Zhang1, Caleb W Holyoke2, Thomas F Pahutski2, George P Lahm2, James D Barry2, Daniel Cordova2, Robert M Leighty2, Vineet Singh3, Daniel R Vicent2, My-Hanh T Tong2, Kenneth A Hughes2, Stephen F McCann2, Yewande T Henry2, Ming Xu2, Twyla A Briddell2.
Abstract
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program which led to the discovery of triflumezopyrim as a highly potent insecticide controlling various hopper species. Our efforts in discovery, synthesis, structure-activity relationship elucidation, and biological activity evaluation are also presented. Copyright ÂEntities:
Keywords: Acetylcholine receptor; Inhibitor; Insecticide; Mesoionic; Pyrido[1,2-a]pyrimidinone; Triflumezopyrim
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Year: 2016 PMID： 27894871 DOI： 10.1016/j.bmcl.2016.11.042
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823