Literature DB >> 27894362

The trypanosome alternative oxidase: a potential drug target?

Stefanie K Menzies1, Lindsay B Tulloch1, Gordon J Florence1, Terry K Smith1.   

Abstract

New drugs against Trypanosoma brucei, the causative agent of Human African Trypanosomiasis, are urgently needed to replace the highly toxic and largely ineffective therapies currently used. The trypanosome alternative oxidase (TAO) is an essential and unique mitochondrial protein in these parasites and is absent from mammalian mitochondria, making it an attractive drug target. The structure and function of the protein are now well characterized, with several inhibitors reported in the literature, which show potential as clinical drug candidates. In this review, we provide an update on the functional activity and structural aspects of TAO. We then discuss TAO inhibitors reported to date, problems encountered with in vivo testing of these compounds, and discuss the future of TAO as a therapeutic target.

Entities:  

Keywords:  zzm321990 Trypanosoma bruceizzm321990 ; Trypanosome alternative oxidase; chemotherapy; drug discovery; human African trypanosomiasis; sleeping sickness

Mesh：

Substances：

Year:  2016        PMID： 27894362     DOI： 10.1017/S0031182016002109

Source DB:  PubMed          Journal:  Parasitology        ISSN： 0031-1820            Impact factor:   3.234


  12 in total

1.  SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase.

Authors:  Alejandro Meco-Navas; Godwin U Ebiloma; Ana Martín-Domínguez; Irene Martínez-Benayas; Eduardo J Cueto-Díaz; Amani Saud Alhejely; Emmanuel O Balogun; Machi Saito; Miho Matsui; Natsumi Arai; Tomoo Shiba; Shigeharu Harada; Harry P de Koning; Christophe Dardonville
Journal:  ACS Med Chem Lett       Date:  2018-07-31       Impact factor: 4.345

2.  Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species.

Authors:  Erofili Giannakopoulou; Vasiliki Pardali; Efseveia Frakolaki; Vasileios Siozos; Vassilios Myrianthopoulos; Emmanuel Mikros; Martin C Taylor; John M Kelly; Niki Vassilaki; Grigoris Zoidis
Journal:  Medchemcomm       Date:  2019-05-16       Impact factor: 3.597

3.  Microbial protein targets: towards understanding and intervention.

Authors:  Paul W Denny
Journal:  Parasitology       Date:  2017-11-16       Impact factor: 3.234

Review 4.  The potential of respiration inhibition as a new approach to combat human fungal pathogens.

Authors:  Lucian Duvenage; Carol A Munro; Campbell W Gourlay
Journal:  Curr Genet       Date:  2019-06-06       Impact factor: 3.886

5.  QSAR and molecular docking for the search of AOX inhibitors: a rational drug discovery approach.

Authors:  Alicia Rosell-Hidalgo; Luke Young; Anthony L Moore; Taravat Ghafourian
Journal:  J Comput Aided Mol Des       Date:  2020-12-08       Impact factor: 3.686

6.  Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure-Activity Relationship Studies.

Authors:  David Cisneros; Eduardo J Cueto-Díaz; Tania Medina-Gil; Rebecca Chevillard; Teresa Bernal-Fraile; Ramón López-Sastre; Mustafa M Aldfer; Marzuq A Ungogo; Hamza A A Elati; Natsumi Arai; Momoka Otani; Shun Matsushiro; Chiaki Kojima; Godwin U Ebiloma; Tomoo Shiba; Harry P de Koning; Christophe Dardonville
Journal:  ACS Med Chem Lett       Date:  2022-01-28       Impact factor: 4.345

Review 7.  Mitochondria as a therapeutic target for common pathologies.

Authors:  Michael P Murphy; Richard C Hartley
Journal:  Nat Rev Drug Discov       Date:  2018-11-05       Impact factor: 84.694

Review 8.  Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life.

Authors:  Deborah M Boes; Albert Godoy-Hernandez; Duncan G G McMillan
Journal:  Membranes (Basel)       Date:  2021-05-08

9.  Partially Purified Leaf Fractions of Azadirachta indica Inhibit Trypanosome Alternative Oxidase and Exert Antitrypanosomal Effects on Trypanosoma congolense.

Authors:  Abdullah M Tauheed; Mohammed Mamman; Abubakar Ahmed; Mohammed M Suleiman; Emmanuel O Balogun
Journal:  Acta Parasitol       Date:  2021-06-22       Impact factor: 1.534

Review 10.  New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story.

Authors:  Emily A Dickie; Federica Giordani; Matthew K Gould; Pascal Mäser; Christian Burri; Jeremy C Mottram; Srinivasa P S Rao; Michael P Barrett
Journal:  Trop Med Infect Dis       Date:  2020-02-19
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.