Literature DB >> 27892608

An advanced mouse model for human skin wound healing.

Jie Wen1, Xiangyong Li1,2, Xue Leng1, Xin Xu1, Xunwei Wu1.   

Abstract

Here, we report a model for studying wound repair based on skin regenerated from human tissue culture-expanded cells. The reconstituted skin (hRSK) responds to injury similar to that of intact human skin, and its constituent cells contribute to the healing process. As we have demonstrated that hRSK composed of GFP-labelled cells also heals "normally," we believe this model will be useful in analysing the wound repair process using genetically modified human cells.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  cultured cells; human reconstituted skin; mouse model; regeneration; wound healing

Mesh：

Year:  2017        PMID： 27892608     DOI： 10.1111/exd.13258

Source DB:  PubMed          Journal:  Exp Dermatol        ISSN： 0906-6705            Impact factor:   3.960


  5 in total

1.  Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo.

Authors:  Guo-You Zhang; Ewan A Langan; Natalia T Meier; Wolfgang Funk; Frank Siemers; Ralf Paus
Journal:  PLoS One       Date:  2019-03-29       Impact factor: 3.240

2.  Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems.

Authors:  Yiqun Su; Jie Wen; Junrong Zhu; Zhiwei Xie; Chang Liu; Chuan Ma; Qun Zhang; Xin Xu; Xunwei Wu
Journal:  Stem Cell Res Ther       Date:  2019-12-19       Impact factor: 6.832

3.  Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivo.

Authors:  H Post; J E Hundt; E A Langan; R Paus; G Zhang; R Depping; C Rose
Journal:  Arch Dermatol Res       Date:  2020-06-22       Impact factor: 3.017

4.  Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes.

Authors:  Guanyi Liu; Dingyang Li; Liwei Zhang; Qiuping Xu; Dexuan Zhuang; Panpan Liu; Ling Hu; Huiting Deng; Jianfeng Sun; Shuangshuang Wang; Bin Zheng; Jing Guo; Xunwei Wu
Journal:  Cells       Date:  2022-08-05       Impact factor: 7.666

5.  A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells.

Authors:  Jie Wen; Wenqian Chen; Baoxiang Zhao; Qiuping Xu; Chang Liu; Qun Zhang; Zhiwei Xie; Yonggan Yan; Jing Guo; Jun Huang; Junying Miao; Xunwei Wu
Journal:  Cell Death Dis       Date:  2021-06-08       Impact factor: 8.469
  5 in total

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