Literature DB >> 27892554

An α-helical peptidomimetic scaffold for dynamic combinatorial library formation.

Nathalie Busschaert1, Sam Thompson2, Andrew D Hamilton1.   

Abstract

A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.

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Year:  2016        PMID： 27892554     DOI： 10.1039/c6cc07787k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Generation of Dynamic Combinatorial Libraries Using Hydrazone-Functionalized Surface Mimetics.

Authors:  Sarah H Hewitt; Andrew J Wilson
Journal:  European J Org Chem       Date:  2018-04-25

2.  A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 5: A Complete Set of Pyridine Boronic Acid Pinacol Esters Featuring Side Chains of Proteinogenic Amino Acids.

Authors:  Melanie Trobe; Till Schreiner; Martin Vareka; Sebastian Grimm; Bernhard Wölfl; Rolf Breinbauer
Journal:  European J Org Chem       Date:  2022-02-24

3.  Dynamic Covalent Chemistry of Aldehyde Enamines: BiIII - and ScIII -Catalysis of Amine-Enamine Exchange.

Authors:  Yang Zhang; Sheng Xie; Mingdi Yan; Olof Ramström
Journal:  Chemistry       Date:  2017-08-09       Impact factor: 5.236
  3 in total

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