V Anandan1, W Afthab Jameela2, P Saraswathy3, S Sarankumar4. 1. Professor and Head of Department, Department of Dermatology, Stanley Medical College and Hospital , Chennai, Tamil Nadu, India . 2. Associate Professor, Department of Dermatology, Stanley Medical College and Hospital , Chennai, Tamil Nadu, India . 3. Assistant Professor, Department of Dermatology, Stanley Medical College and Hospital , Chennai, Tamil Nadu, India . 4. Postgraduate, Department of Dermatology, Stanley Medical College and Hospital , Chennai, Tamil Nadu, India .
Abstract
INTRODUCTION: Trophic ulcers secondary to leprosy pose a great stigma to the patients and remain a challenge to the treating dermatologists. The discovery of Platelet Rich Plasma (PRP) with its favourable role in wound healing is a boon for the patients. PRP introduces the growth factors directly into the wound and aids in rapid healing. AIM: To study the efficacy and safety of PRP in the healing of trophic ulcers secondary to Hansen's disease in a tertiary care centre in Southern India. MATERIALS AND METHODS: Based on inclusion and exclusion criteria, 50 patients were enrolled in the study. PRP was prepared by manual double spin method. After wound bed preparation, activated PRP was sprayed over the ulcer and occlusive dressings were applied. Same procedure was repeated every week until complete re-epithelisation or up to six sittings whichever occurred earlier. RESULTS: In our study, 46 patients (92%) showed complete healing. In 4 patients (8%), there was marked reduction in wound size with partial re-epithelization. In 88%, complete healing was seen after the fourth sitting. Mean time for ulcer healing was around 4.38 weeks. CONCLUSION: PRP therapy leads to faster rate of induction of granulation tissue with rapid healing. Healing had no direct statistical correlation with the size, site and duration of ulcer, the leprosy spectrum and associated motor deformities. It is a simple, safe and cost effective in-office procedure, albeit requiring an optimal set-up and expertise.
INTRODUCTION:Trophic ulcers secondary to leprosy pose a great stigma to the patients and remain a challenge to the treating dermatologists. The discovery of Platelet Rich Plasma (PRP) with its favourable role in wound healing is a boon for the patients. PRP introduces the growth factors directly into the wound and aids in rapid healing. AIM: To study the efficacy and safety of PRP in the healing of trophic ulcers secondary to Hansen's disease in a tertiary care centre in Southern India. MATERIALS AND METHODS: Based on inclusion and exclusion criteria, 50 patients were enrolled in the study. PRP was prepared by manual double spin method. After wound bed preparation, activated PRP was sprayed over the ulcer and occlusive dressings were applied. Same procedure was repeated every week until complete re-epithelisation or up to six sittings whichever occurred earlier. RESULTS: In our study, 46 patients (92%) showed complete healing. In 4 patients (8%), there was marked reduction in wound size with partial re-epithelization. In 88%, complete healing was seen after the fourth sitting. Mean time for ulcer healing was around 4.38 weeks. CONCLUSION:PRP therapy leads to faster rate of induction of granulation tissue with rapid healing. Healing had no direct statistical correlation with the size, site and duration of ulcer, the leprosy spectrum and associated motor deformities. It is a simple, safe and cost effective in-office procedure, albeit requiring an optimal set-up and expertise.
Authors: Marissa J Carter; Carelyn P Fylling; William W Li; Jean de Leon; Vickie R Driver; Thomas E Serena; Janice Wilson Journal: Int Wound J Date: 2011-09-13 Impact factor: 3.315
Authors: Robert G Frykberg; Vickie R Driver; Donna Carman; Brenda Lucero; Cathy Borris-Hale; Carelyn P Fylling; Laurie M Rappl; Peter A Clausen Journal: Ostomy Wound Manage Date: 2010-06 Impact factor: 2.629
Authors: M Pitiakoudis; A Giatromanolaki; I Iliopoulos; A K Tsaroucha; C Simopoulos; C Piperidou Journal: J Int Med Res Date: 2004 Mar-Apr Impact factor: 1.671