| Literature DB >> 27890240 |
Jennifer M Huang1, Ijeuru Chikeka1, Thomas J Hornyak2.
Abstract
Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation to melanoma. Understanding molecular and cellular mechanisms underlying oncogene-induced senescence should help identify pathways underlying melanoma development, leading to the development of new strategies for melanoma prevention and early detection. Published by Elsevier Inc.Entities:
Keywords: Melanocyte; Melanoma; Nevi; Oncogene; Senescence
Mesh:
Year: 2017 PMID: 27890240 PMCID: PMC5391772 DOI: 10.1016/j.det.2016.08.001
Source DB: PubMed Journal: Dermatol Clin ISSN: 0733-8635 Impact factor: 3.478