A Senthil Kumar1, Aparna Chandrasekaran, Rajamannar Asokan, Kathirvelu Gopinathan. 1. Department of Neonatology, CHILDS Trust Medical Research Foundation and Kanchi Kamakoti CHILDS Trust Hospital, and *Department of Radiology, Kilpauk Medical College; Chennai, Tamil Nadu, India. Correspondence to: Dr Aparna Chandrasekaran, Department of Neonatology, CHILDS Trust Medical Research Foundation and Kanchi Kamakoti CHILDS Trust Hospital, Nungambakkam, Chennai 600 034, Tamil Nadu, India. appubanu@gmail.com.
Abstract
OBJECTIVE: To evaluate the role of Resistive index measured by cranial doppler ultrasonography in predicting the risk of death/ abnormal neurodevelopmental outcomes in term neonates with hypoxic ischemic encephalopathy. METHODS: We enrolled 50 term asphyxiated neonates with hypoxic ischemic encephalopathy and measured resistive index within 72 hours from the anterior cerebral artery. Participants underwent tone and developmental assessment at 6-12 months. RESULTS: Among the 50 neonates, 25 (50%) had abnormal resistive index (<0.56 or >0.80). Presence of abnormal resistive index increased the risk of death/ abnormal neurological outcomes at 6-12 months [RR (95% CI): 7.5 (2.0,8.6), P<0.01]. CONCLUSION: An abnormal resistive index is associated with death/ neurodevelopmental impairment in neonatal hypoxic ischemic encephalopathy.
OBJECTIVE: To evaluate the role of Resistive index measured by cranial doppler ultrasonography in predicting the risk of death/ abnormal neurodevelopmental outcomes in term neonates with hypoxic ischemicencephalopathy. METHODS: We enrolled 50 term asphyxiated neonates with hypoxic ischemicencephalopathy and measured resistive index within 72 hours from the anterior cerebral artery. Participants underwent tone and developmental assessment at 6-12 months. RESULTS: Among the 50 neonates, 25 (50%) had abnormal resistive index (<0.56 or >0.80). Presence of abnormal resistive index increased the risk of death/ abnormal neurological outcomes at 6-12 months [RR (95% CI): 7.5 (2.0,8.6), P<0.01]. CONCLUSION: An abnormal resistive index is associated with death/ neurodevelopmental impairment in neonatal hypoxic ischemicencephalopathy.
Authors: Carol Nanyunja; Samantha Sadoo; Annettee Nakimuli; Cally J Tann; Ivan Mambule; Sean R Mathieson; Moffat Nyirenda; Emily L Webb; J Mugalu; Nicola J Robertson; A Nabawanuka; Guillaume Gilbert; J Bwambale; Kathryn Martinello; Alan Bainbridge; Samson Lubowa; Latha Srinivasan; H Ssebombo; Cathy Morgan; Cornelia Hagmann; Frances M Cowan; Kirsty Le Doare; Pia Wintermark; Michael Kawooya; Geraldine B Boylan Journal: Gates Open Res Date: 2022-03-03