BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) survivors have increased risk of obesity, metabolic alterations and cardiovascular disease (CVD). Vascular endothelial function has been studied in adult cancers. Limited data exist regarding CVD risk factors among childhood ALL survivors. We aimed to assess endothelial function, metabolic and cardiovascular risk factors in young survivors of childhood ALL. METHODS: Auxological parameters, blood pressure, glucose, lipid profile, hemostatic markers (total adiponectin and high-molecular-weight subfraction, endothelin-1, von Willebrand factor antigen, thrombin-antithrombin complex, D-dimers, fibrinogen), high sensitive C-reactive protein and ultrasound parameters of endothelial function (flow-mediated dilation-FMD, common carotid intima-media thickness-C-IMT, and antero-posterior diameter of infra-renal abdominal aorta-APAO) were assessed in 52 ALL survivors and 34 sex and age-matched controls. RESULTS: ALL patients and controls were not statistically different as regards body mass index and waist circumference. Blood pressure, glucose, total and LDL-cholesterol, triglycerides, high sensitive C-reactive protein were statistically higher in ALL than in controls, while HDL-cholesterol was lower in ALL than in controls. Patients showed statistically lower high-molecular-weight adiponectin and thrombin-antithrombin complex (p=0.003 and p<0.001, respectively) and higher vonWillebrand factor antigen (p=0.002) than controls. FMD was lower in patients than in controls (p<0.001). Biomarkers of endothelial function, systolic blood pressure and waist circumference were correlated to FMD. CONCLUSIONS: ALL survivors showed derangement of endothelial function, which likely occurs during chemotherapy and lasts till follow up. They showed metabolic alterations even though obesity was not documented. Endothelial vascular parameters should be evaluated earlier during follow-up to detect preclinical onset of CVD.
BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) survivors have increased risk of obesity, metabolic alterations and cardiovascular disease (CVD). Vascular endothelial function has been studied in adult cancers. Limited data exist regarding CVD risk factors among childhood ALL survivors. We aimed to assess endothelial function, metabolic and cardiovascular risk factors in young survivors of childhood ALL. METHODS: Auxological parameters, blood pressure, glucose, lipid profile, hemostatic markers (total adiponectin and high-molecular-weight subfraction, endothelin-1, von Willebrand factor antigen, thrombin-antithrombin complex, D-dimers, fibrinogen), high sensitive C-reactive protein and ultrasound parameters of endothelial function (flow-mediated dilation-FMD, common carotid intima-media thickness-C-IMT, and antero-posterior diameter of infra-renal abdominal aorta-APAO) were assessed in 52 ALL survivors and 34 sex and age-matched controls. RESULTS: ALL patients and controls were not statistically different as regards body mass index and waist circumference. Blood pressure, glucose, total and LDL-cholesterol, triglycerides, high sensitive C-reactive protein were statistically higher in ALL than in controls, while HDL-cholesterol was lower in ALL than in controls. Patients showed statistically lower high-molecular-weight adiponectin and thrombin-antithrombin complex (p=0.003 and p<0.001, respectively) and higher vonWillebrand factor antigen (p=0.002) than controls. FMD was lower in patients than in controls (p<0.001). Biomarkers of endothelial function, systolic blood pressure and waist circumference were correlated to FMD. CONCLUSIONS: ALL survivors showed derangement of endothelial function, which likely occurs during chemotherapy and lasts till follow up. They showed metabolic alterations even though obesity was not documented. Endothelial vascular parameters should be evaluated earlier during follow-up to detect preclinical onset of CVD.
Authors: Alberto Romano; Ester Del Vescovo; Serena Rivetti; Silvia Triarico; Giorgio Attinà; Stefano Mastrangelo; Palma Maurizi; Antonio Ruggiero Journal: J Pers Med Date: 2022-05-27
Authors: Abiodun Oluyomi; K Danielle Aldrich; Kayla L Foster; Hoda Badr; Kala Y Kamdar; Michael E Scheurer; Philip J Lupo; Austin L Brown Journal: J Cancer Surviv Date: 2020-11-23 Impact factor: 4.062
Authors: Lorrany da Rosa Santos; Silvan Silva de Araujo; Erlânyo Francisco Dos Santos Vieira; Charles Dos Santos Estevam; Jymmys Lopes Dos Santos; Rogério Brandão Wichi; Fábio Bessa Lima; Carla Roberta Oliveira Carvalho; Felipe José Aidar; Anderson Carlos Marçal Journal: Medicina (Kaunas) Date: 2020-05-06 Impact factor: 2.430
Authors: Laila M Sherief; Elhamy R Abd El-Khalek; Ibrahim A Libda; Osama A Gaber; Naglaa M Kamal; Basma K Soliman; Wesam A Mokhtar; Ghada A Mokhtar; Hosam E Salah; Gehad M Kamar; Marwa Zakaria Journal: Ther Adv Chronic Dis Date: 2021-05-25 Impact factor: 5.091
Authors: Agostino Milluzzo; Lucia Manuella; Emanuela Cannata; Giovanna Russo; Sandro La Vignera; Francesco Purrello; Andrea Di Cataldo; Laura Sciacca Journal: J Clin Med Date: 2022-02-07 Impact factor: 4.241
Authors: Barbara Reiner; Irene Schmid; Thorsten Schulz; Jan Müller; Alfred Hager; Julia Hock; Peter Ewert; Cordula Wolf; Renate Oberhoffer-Fritz; Jochen Weil Journal: J Clin Med Date: 2022-01-26 Impact factor: 4.241