| Literature DB >> 27889034 |
Chia-Ching J Wang1, Joseph Sparano2, Joel M Palefsky3.
Abstract
Anal cancer is an increasingly common non-AIDS-defining cancer among individuals infected with the human immunodeficiency virus (HIV). It is associated with human papillomavirus (HPV). HPV16 is the most common genotype detected in anal cancers. The HPV types detected in anal cancer are included in the 9-valent vaccine. HPV vaccines have demonstrated efficacy in reducing anal precancerous lesions in HIV-infected individuals. Standard treatment has been fluorouracil and mitomycin (or cisplatin) plus radiation. Continued studies are needed to test new treatment strategies in HIV-infected patients with anal cancer to determine which treatment protocols provide the best therapeutic index. Copyright ÂEntities:
Keywords: Anal cancer; HIV; HPV; HPV vaccination; Immunosuppression
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Year: 2017 PMID: 27889034 PMCID: PMC5331942 DOI: 10.1016/j.soc.2016.07.010
Source DB: PubMed Journal: Surg Oncol Clin N Am ISSN: 1055-3207 Impact factor: 3.495