Qinghua Ma1, Jinwen Wang2, Jing Jin3, Ming Gao4, Fang Liu2, Shanshan Zhou3, Feng Tian3, Jie Liu3, Yuqi Liu5, Yundai Chen6. 1. Department of Cardiology, Yishui Center Hospital of Shandong Province, Linyi 276000, China. 2. Department of Cardiology, AnZhen Hospital, Beijing 100029, China. 3. Department of Cardiology, PLA General Hospital, Beijing 100853, China. 4. ICU of The First Phase Beijing Tsinghua Changgeng Hospital, Beijing 100044, China. 5. Department of Cardiology, PLA General Hospital, Beijing 100853, China. Electronic address: ametuofo980869@163.com. 6. Department of Cardiology, PLA General Hospital, Beijing 100853, China. Electronic address: cyundai@vip.163.com.
Abstract
OBJECTIVES: The clinical characteristics and prognosis of young women (≤50years) with acute coronary syndrome (ACS) are still unclear. METHODS: A total of 5196 patients with ACS were enrolled from the cardiac center of Chinese PLA General Hospital and Anzhen Hospital. The clinical characteristics of these patients were analyzed. Then the PubMed, EMBASE, and Cochrane Central Register of Controlled Trials electronic databases were searched from January 2001 to July 2016. Clinical trials that performed comparisons prognosis of young women versus men with ACS were considered for inclusion. RESULTS: The young men had higher BMI, had increased incidence of hyperlipidemia, and were more likely to smoke, drink alcohol, and have had a previous MI. There was a higher proportion of unstable angina (UA) in women than in men (P<0.05). The proportion of thrombolysis myocardial infarction (TIMI) 0 in women was lower than in men (P=0.001), and the proportion of TIMI 3 was higher in women than in men (P=0.000). The mortality of in-hospital, short-term, and long-term rate was significantly higher in women than that in men (6.2% vs 2.9%, OR=1.84, P<0.001; 16.4% vs 11.5%, OR=1.66, P=0.007; 8.9% vs 3.0%, OR=1.41, P=0.008), but there were no significant differences in the rates of major adverse cardiac events (MACE). CONCLUSIONS: In young women patients with ACS, the mortality rate during in-hospital, short-term, and longer-term follow-up in women was higher than that in men. Thus, young women with ACS need more attention during clinical diagnosis and treatment.
OBJECTIVES: The clinical characteristics and prognosis of young women (≤50years) with acute coronary syndrome (ACS) are still unclear. METHODS: A total of 5196 patients with ACS were enrolled from the cardiac center of Chinese PLA General Hospital and Anzhen Hospital. The clinical characteristics of these patients were analyzed. Then the PubMed, EMBASE, and Cochrane Central Register of Controlled Trials electronic databases were searched from January 2001 to July 2016. Clinical trials that performed comparisons prognosis of young women versus men with ACS were considered for inclusion. RESULTS: The young men had higher BMI, had increased incidence of hyperlipidemia, and were more likely to smoke, drink alcohol, and have had a previous MI. There was a higher proportion of unstable angina (UA) in women than in men (P<0.05). The proportion of thrombolysis myocardial infarction (TIMI) 0 in women was lower than in men (P=0.001), and the proportion of TIMI 3 was higher in women than in men (P=0.000). The mortality of in-hospital, short-term, and long-term rate was significantly higher in women than that in men (6.2% vs 2.9%, OR=1.84, P<0.001; 16.4% vs 11.5%, OR=1.66, P=0.007; 8.9% vs 3.0%, OR=1.41, P=0.008), but there were no significant differences in the rates of major adverse cardiac events (MACE). CONCLUSIONS: In young womenpatients with ACS, the mortality rate during in-hospital, short-term, and longer-term follow-up in women was higher than that in men. Thus, young women with ACS need more attention during clinical diagnosis and treatment.
Authors: Dinh The Anh; Huynh Van Minh; Ho Anh Binh; Tran Quang Bao; Nguyen Thi Thai Hai; Le Xuan Nam; Tran Duc Anh Journal: J Transl Int Med Date: 2021-03-31