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Literature DB >> 27888348

Pathogenesis of COPD and Asthma.

Clive Page¹, Blaze O'Shaughnessy², Peter Barnes³.

Abstract

Asthma and COPD remain two diseases of the respiratory tract with unmet medical needs. This review considers the current state of play with respect to what is known about the underlying pathogenesis of these two chronic inflammatory diseases of the lung. The review highlights why they are different conditions requiring different approaches to treatment and provides a backdrop for the subsequent chapters in this volume discussing recent advances in the pharmacology and treatment of asthma and COPD.

Entities: Disease

Keywords: Asthma; Bronchial hyperresponsiveness; COPD; Pathogenesis

Mesh：

Year: 2017 PMID： 27888348 DOI： 10.1007/164_2016_61

Source DB: PubMed Journal: Handb Exp Pharmacol ISSN： 0171-2004

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Cited

8 in total

1. Plk1 Regulates Caspase-9 Phosphorylation at Ser-196 and Apoptosis of Human Airway Smooth Muscle Cells.

Authors: Guoning Liao; Ruping Wang; Dale D Tang
Journal: Am J Respir Cell Mol Biol Date: 2022-02 Impact factor: 6.914

2. Identification of the key genes in chronic obstructive pulmonary disease by weighted gene co-expression network analysis.

Authors: Zhefan Xie; Tingting Xia; Dongxue Wu; Li Che; Wei Zhang; Xingdong Cai; Shengming Liu
Journal: Ann Transl Med Date: 2022-06

3. Functional contribution of sphingosine-1-phosphate to airway pathology in cigarette smoke-exposed mice.

Authors: Giovanna De Cunto; Vincenzo Brancaleone; Maria Antonietta Riemma; Ida Cerqua; Valentina Vellecco; Giuseppe Spaziano; Eleonora Cavarra; Barbara Bartalesi; Bruno D'Agostino; Giuseppe Lungarella; Giuseppe Cirino; Monica Lucattelli; Fiorentina Roviezzo
Journal: Br J Pharmacol Date: 2019-11-06 Impact factor: 8.739

4. Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics: Relationships with Disease Severity and Infiltration of Inflammatory Cells.

Authors: Ting Yang; Yan Li; Zhe Lyu; Kewu Huang; Chris J Corrigan; Sun Ying; Wei Wang; Chen Wang
Journal: Chin Med J (Engl) Date: 2017-09-05 Impact factor: 2.628

5. Differential coexpression networks in bronchiolitis and emphysema phenotypes reveal heterogeneous mechanisms of chronic obstructive pulmonary disease.

Authors: Jiangyue Qin; Ting Yang; Ni Zeng; Chun Wan; Lijuan Gao; Xiaoou Li; Lei Chen; Yongchun Shen; Fuqiang Wen
Journal: J Cell Mol Med Date: 2019-08-16 Impact factor: 5.310

Pathogenesis of COPD and Asthma.

1. Plk1 Regulates Caspase-9 Phosphorylation at Ser-196 and Apoptosis of Human Airway Smooth Muscle Cells.

2. Identification of the key genes in chronic obstructive pulmonary disease by weighted gene co-expression network analysis.

3. Functional contribution of sphingosine-1-phosphate to airway pathology in cigarette smoke-exposed mice.

4. Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics: Relationships with Disease Severity and Infiltration of Inflammatory Cells.

5. Differential coexpression networks in bronchiolitis and emphysema phenotypes reveal heterogeneous mechanisms of chronic obstructive pulmonary disease.

6. Fixed-Dose Combinations of Long-Acting Bronchodilators for the Management of COPD: Global and Asian Perspectives.

7. Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling.

Review 8. Current Understanding of Asthma Pathogenesis and Biomarkers.