Literature DB >> 27888069

Vertebrate embryos as tools for anti-angiogenic drug screening and function.

Shaunna L Beedie1, Alexandra J Diamond2, Lucas Rosa Fraga2, William D Figg3, Neil Vargesson4.   

Abstract

The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Angiogenesis; Chicken; Mouse; Non-human primates; Rabbit; Rat; Thalidomide; Zebrafish

Mesh：

Substances：

Year:  2016        PMID： 27888069      PMCID： PMC6357960          DOI： 10.1016/j.reprotox.2016.11.013

Source DB:  PubMed          Journal:  Reprod Toxicol        ISSN： 0890-6238            Impact factor:   3.143


  4 in total

1.  Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities.

Authors:  Weiming Luo; David Tweedie; Shaunna L Beedie; Neil Vargesson; William D Figg; Nigel H Greig; Michael T Scerba
Journal:  Bioorg Med Chem       Date:  2018-02-10       Impact factor: 3.641

2.  The Primodos components Norethisterone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafish embryos.

Authors:  Samantha Brown; Lucas Rosa Fraga; Gary Cameron; Lynda Erskine; Neil Vargesson
Journal:  Sci Rep       Date:  2018-02-13       Impact factor: 4.379

3.  Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor.

Authors:  Antonio N Mauro; Paul J Turgeon; Sahil Gupta; Koroboshka Brand-Arzamendi; Hao Chen; Jeanie H Malone; Robin Ng; Kevin Ho; Michelle Dubinsky; Caterina Di Ciano-Oliveira; Christopher Spring; Pamela Plant; Howard Leong-Poi; John C Marshall; Philip A Marsden; Kim A Connelly; Krishna K Singh
Journal:  Sci Rep       Date:  2022-08-25       Impact factor: 4.996

Review 4.  From the Farm to the Lab: How Chicken Embryos Contribute to the Field of Teratology.

Authors:  Gabriela Elis Wachholz; Bruna Duarte Rengel; Neil Vargesson; Lucas Rosa Fraga
Journal:  Front Genet       Date:  2021-07-22       Impact factor: 4.599
  4 in total

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