Literature DB >> 27886910

Current and Future Biomarkers in Atopic Dermatitis.

Judith L Thijs1, Marjolein S de Bruin-Weller1, DirkJan Hijnen2.   

Abstract

Atopic dermatitis (AD) is a heterogeneous disease and many attempts have been made to define subsets of patients based on clinical characteristics. However, the current characterization of patients with AD might not adequately reflect the pathophysiologic diversity within patients with AD. This article reviews current biomarkers for AD and future perspectives. In the future, patients with AD will be stratified based on biomarker expression levels in body fluids and tissue, genetic variants, or combined biomarker expression patterns. With new targeted therapies for AD currently investigated in clinical trials this will lead to better identification of patients that can benefit from these highly specific, but expensive new treatments. Copyright Â
© 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Atopic dermatitis; Biologicals; Biomarkers; Disease severity; Heterogeneity; Personalized medicine; Stratification

Mesh:

Substances:

Year:  2016        PMID: 27886910     DOI: 10.1016/j.iac.2016.08.008

Source DB:  PubMed          Journal:  Immunol Allergy Clin North Am        ISSN: 0889-8561            Impact factor:   3.479


  6 in total

1.  Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling.

Authors:  Thien T P Dao; Kwangho Song; Jee Young Kim; Yeong Shik Kim
Journal:  Inflamm Res       Date:  2020-01-30       Impact factor: 4.575

Review 2.  Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches.

Authors:  Matthew Moyle; Ferda Cevikbas; Jamie L Harden; Emma Guttman-Yassky
Journal:  Exp Dermatol       Date:  2019-04-15       Impact factor: 3.960

Review 3.  Personalized medicine-concepts, technologies, and applications in inflammatory skin diseases.

Authors:  Thomas Litman
Journal:  APMIS       Date:  2019-05       Impact factor: 3.205

4.  Gingival Crevicular Fluid Zinc- and Aspartyl-Binding Protease Profile of Individuals with Moderate/Severe Atopic Dermatitis.

Authors:  Fernando Valenzuela; Javier Fernández; Marcela Aroca; Constanza Jiménez; Daniela Albers; Marcela Hernández; Alejandra Fernández
Journal:  Biomolecules       Date:  2020-11-26

Review 5.  Atopic Dermatitis: Striving for Reliable Biomarkers.

Authors:  Styliani Mastraftsi; Georgia Vrioni; Michail Bakakis; Electra Nicolaidou; Dimitrios Rigopoulos; Alexander J Stratigos; Stamatios Gregoriou
Journal:  J Clin Med       Date:  2022-08-09       Impact factor: 4.964

6.  Skullcapflavone II Suppresses TNF-α/IFN-γ-Induced TARC, MDC, and CTSS Production in HaCaT Cells.

Authors:  Hanon Lee; Dong Hun Lee; Jang-Hee Oh; Jin Ho Chung
Journal:  Int J Mol Sci       Date:  2021-06-16       Impact factor: 6.208

  6 in total

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