| Literature DB >> 27886910 |
Judith L Thijs1, Marjolein S de Bruin-Weller1, DirkJan Hijnen2.
Abstract
Atopic dermatitis (AD) is a heterogeneous disease and many attempts have been made to define subsets of patients based on clinical characteristics. However, the current characterization of patients with AD might not adequately reflect the pathophysiologic diversity within patients with AD. This article reviews current biomarkers for AD and future perspectives. In the future, patients with AD will be stratified based on biomarker expression levels in body fluids and tissue, genetic variants, or combined biomarker expression patterns. With new targeted therapies for AD currently investigated in clinical trials this will lead to better identification of patients that can benefit from these highly specific, but expensive new treatments. Copyright ÂEntities:
Keywords: Atopic dermatitis; Biologicals; Biomarkers; Disease severity; Heterogeneity; Personalized medicine; Stratification
Mesh:
Substances:
Year: 2016 PMID: 27886910 DOI: 10.1016/j.iac.2016.08.008
Source DB: PubMed Journal: Immunol Allergy Clin North Am ISSN: 0889-8561 Impact factor: 3.479