Literature DB >> 27886556

Modular delivery of CpG-incorporated lipid-DNA nanoparticles for spleen DC activation.

Jun-O Jin1, Haein Park2, Wei Zhang1, Jan Willem de Vries3, Agnieszka Gruszka3, Myung Won Lee2, Dae-Ro Ahn4, Andreas Herrmann5, Minseok Kwak6.   

Abstract

We introduce a versatile carrier system for in vitro and in vivo immune stimulation based on soft matter DNA nanoparticles (NPs). The incorporation of lipid-modified nucleotides into DNA strands enables the formation of micelles of uniform size. In a single self-assembly step, the micelles can be equipped with immune adjuvant (CpG) motifs and fluorescent probes. The immunological effects of CpG confined at the NP surface were studied in a comprehensive manner in animal experiments. Dose-dependent activation of spleen dendritic cells (DCs) by CpG-conjugated NP was observed, which was accompanied by the pronounced up-regulation of co-stimulatory molecule and cytokine production. Copyright Â
© 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Adjuvants; DNA nanotechnology; Dendritic cells; Immunology; Nanomedicine

Mesh：

Substances：

Year:  2016        PMID： 27886556     DOI： 10.1016/j.biomaterials.2016.11.020

Source DB:  PubMed          Journal:  Biomaterials        ISSN： 0142-9612            Impact factor:   12.479


  9 in total

1.  Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation.

Authors:  Jun-O Jin; Soyeong Jang; Hyehyun Kim; Junghwan Oh; Sungbo Shim; Minseok Kwak; Peter C W Lee
Journal:  J Vis Exp       Date:  2018-09-16       Impact factor: 1.355

2.  Self-Assembly as a Molecular Strategy to Improve Immunotherapy.

Authors:  Eugene Froimchuk; Sean T Carey; Camilla Edwards; Christopher M Jewell
Journal:  Acc Chem Res       Date:  2020-10-19       Impact factor: 22.384

3.  Monophosphoryl lipid A-induced activation of plasmacytoid dendritic cells enhances the anti-cancer effects of anti-PD-L1 antibodies.

Authors:  Wei Zhang; Seong-Min Lim; Juyoung Hwang; Srinivasan Ramalingam; Myunghee Kim; Jun-O Jin
Journal:  Cancer Immunol Immunother       Date:  2020-09-09       Impact factor: 6.968

4.  RNA Micelles for the Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand.

Authors:  Hongran Yin; Hongzhi Wang; Zhefeng Li; Dan Shu; Peixuan Guo
Journal:  ACS Nano       Date:  2018-12-19       Impact factor: 15.881

5.  Construction of nanocarriers based on nucleic acids and their applications in nanobiology delivery systems.

Authors:  Yingshu Guo; Xiuping Cao; Xiaofei Zheng; S K Jahir Abbas; Juan Li; Weihong Tan
Journal:  Natl Sci Rev       Date:  2022-01-17       Impact factor: 23.178

Review 6.  Improving Vaccine and Immunotherapy Design Using Biomaterials.

Authors:  Michelle L Bookstaver; Shannon J Tsai; Jonathan S Bromberg; Christopher M Jewell
Journal:  Trends Immunol       Date:  2017-12-14       Impact factor: 16.687

Review 7.  Integrating Biomaterials and Immunology to Improve Vaccines Against Infectious Diseases.

Authors:  Lampouguin Yenkoidiok-Douti; Christopher M Jewell
Journal:  ACS Biomater Sci Eng       Date:  2020-01-12

Review 8.  Engineering self-assembled materials to study and direct immune function.

Authors:  Lisa H Tostanoski; Christopher M Jewell
Journal:  Adv Drug Deliv Rev       Date:  2017-04-06       Impact factor: 15.470

Review 9.  DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy.

Authors:  Qingjia Chi; Zichang Yang; Kang Xu; Chunli Wang; Huaping Liang
Journal:  Front Pharmacol       Date:  2020-01-28       Impact factor: 5.810
  9 in total

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