AIM: The study was aimed at investigation of several gene variants of folate pathway enzymes for their potential association with methotrexate (MTX) treatment response in patients with rheumatoid arthritis. PATIENTS & METHODS: Four hundred and twenty two Caucasian patients were classified as good or poor responders, and subsequently genotyped for common SNPs in DHFR, FPGS and ATIC genes. RESULTS: No significant differences were observed in case of DHFR and FGPS SNPs. As for ATIC rs2372536 (Thr116Ser), GG minor genotype was significantly associated with good response to MTX (OR: 2.40; 95% CI: 1.30-4.42; p = 0.005), which was confirmed by multivariate analysis. CONCLUSION: The results of the study suggest that ATIC missense rs2372536 SNP may influence response to MTX therapy in rheumatoid arthritis patients.
AIM: The study was aimed at investigation of several gene variants of folate pathway enzymes for their potential association with methotrexate (MTX) treatment response in patients with rheumatoid arthritis. PATIENTS & METHODS: Four hundred and twenty two Caucasian patients were classified as good or poor responders, and subsequently genotyped for common SNPs in DHFR, FPGS and ATIC genes. RESULTS: No significant differences were observed in case of DHFR and FGPS SNPs. As for ATICrs2372536 (Thr116Ser), GG minor genotype was significantly associated with good response to MTX (OR: 2.40; 95% CI: 1.30-4.42; p = 0.005), which was confirmed by multivariate analysis. CONCLUSION: The results of the study suggest that ATIC missense rs2372536 SNP may influence response to MTX therapy in rheumatoid arthritispatients.
Authors: Karla Beatriz Cardias Cereja Pantoja; Tereza Cristina de Brito Azevedo; Darlen Cardoso de Carvalho; Natasha Monte; Amanda de Nazaré Cohen Paes; Maria Clara da Costa Barros; Lui Wallacy Morikawa Souza Vinagre; Ana Rosa Sales de Freitas; Rommel Mario Rodríguez Burbano; Paulo Pimentel de Assumpção; Sidney Emanuel Batista Dos Santos; Marianne Rodrigues Fernandes; Ney Pereira Carneiro Dos Santos Journal: Genes (Basel) Date: 2022-02-10 Impact factor: 4.096