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Literature DB >> 27885722

Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation.

Yuqi Zhang¹, Jicheng Yu¹, Jinqiang Wang¹, Nicholas J Hanne¹, Zheng Cui², Chenggen Qian¹, Chao Wang¹, Hongliang Xin¹, Jacqueline H Cole¹, Caterina M Gallippi¹, Yong Zhu¹, Zhen Gu¹.

Abstract

A thrombin-responsive closed-loop patch is developed for prolonged heparin delivery in a feedback-controlled manner. This microneedle-based patch can sense activated thrombin and subsequently releases heparin to prevent coagulation in the blood flow. This "smart" heparin patch can be transcutaneously inserted into skin without drug leakage and can sustainably regulate blood coagulation in response to thrombin.

Entities: Chemical Disease Gene Species

Keywords: anticoagulation; closed-loop; drug delivery; heparin; thrombin-responsive

Mesh：

Substances：

Year: 2016 PMID： 27885722 PMCID： PMC5250559 DOI： 10.1002/adma.201604043

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

35 in total

1. Heparin-coated colloidal mesoporous silica nanoparticles efficiently bind to antithrombin as an anticoagulant drug-delivery system.

Authors: Christian Argyo; Valentina Cauda; Hanna Engelke; Joachim Rädler; Gregor Bein; Thomas Bein
Journal: Chemistry Date: 2011-12-12 Impact factor: 5.236

2. Anticoagulant action of heparin.

Authors: P S Damus; M Hicks; R D Rosenberg
Journal: Nature Date: 1973-12-07 Impact factor: 49.962

3. A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time.

Authors: D Basu; A Gallus; J Hirsh; J Cade
Journal: N Engl J Med Date: 1972-08-17 Impact factor: 91.245

4. Heparin kinetics in venous thrombosis and pulmonary embolism.

Authors: J Hirsh; W G van Aken; A S Gallus; C T Dollery; J F Cade; W L Yung
Journal: Circulation Date: 1976-04 Impact factor: 29.690

5. Thrombolytic activity of BB-10153, a thrombin-activatable plasminogen.

Authors: M B Comer; K S Cackett; S Gladwell; L M Wood; K M Dawson
Journal: J Thromb Haemost Date: 2005-01 Impact factor: 5.824

6. Thrombin specificity. Requirement for apolar amino acids adjacent to the thrombin cleavage site of polypeptide substrate.

Authors: J Y Chang
Journal: Eur J Biochem Date: 1985-09-02

Review 7. Thrombosis as an intravascular effector of innate immunity.

Authors: Bernd Engelmann; Steffen Massberg
Journal: Nat Rev Immunol Date: 2012-12-07 Impact factor: 53.106

8. Dissolving polymer microneedle patches for influenza vaccination.

Authors: Sean P Sullivan; Dimitrios G Koutsonanos; Maria Del Pilar Martin; Jeong Woo Lee; Vladimir Zarnitsyn; Seong-O Choi; Niren Murthy; Richard W Compans; Ioanna Skountzou; Mark R Prausnitz
Journal: Nat Med Date: 2010-07-18 Impact factor: 53.440

9. Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment F1 + 2.

Authors: M D Boisclair; D A Lane; H Philippou; S Sheikh; B Hunt
Journal: Thromb Haemost Date: 1993-08-02 Impact factor: 5.249

10. Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis.

Authors: Paolo Prandoni; Anthonie W A Lensing; Andrea Piccioli; Enrico Bernardi; Paolo Simioni; Bruno Girolami; Antonio Marchiori; Paola Sabbion; Martin H Prins; Franco Noventa; Antonio Girolami
Journal: Blood Date: 2002-07-12 Impact factor: 22.113

21 in total

Review 1. Polymeric microneedles for transdermal protein delivery.

Authors: Yanqi Ye; Jicheng Yu; Di Wen; Anna R Kahkoska; Zhen Gu
Journal: Adv Drug Deliv Rev Date: 2018-01-31 Impact factor: 15.470

Review 2. Glucose-Responsive Microneedle Patches for Diabetes Treatment.

Authors: Guojun Chen; Jicheng Yu; Zhen Gu
Journal: J Diabetes Sci Technol Date: 2018-05-31

3. Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment.

Authors: Yuqi Zhang; Qiongming Liu; Jicheng Yu; Shuangjiang Yu; Jinqiang Wang; Li Qiang; Zhen Gu
Journal: ACS Nano Date: 2017-09-15 Impact factor: 15.881

4. The preparation of heparin-like hyperbranched polyimides and their antithrombogenic, antibacterial applications.

Authors: Qing Li; Jing Li; Guangfu Liao; Zushun Xu
Journal: J Mater Sci Mater Med Date: 2018-07-28 Impact factor: 3.896

Review 5. Bioresponsive transcutaneous patches.

Authors: Jicheng Yu; Yuqi Zhang; Anna R Kahkoska; Zhen Gu
Journal: Curr Opin Biotechnol Date: 2017-03-11 Impact factor: 9.740

Review 6. Integration of biological systems with electronic-mechanical assemblies.

Authors: Ning Yi; Haitao Cui; Lijie Grace Zhang; Huanyu Cheng
Journal: Acta Biomater Date: 2019-04-17 Impact factor: 8.947

Review 7. Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction.

Authors: Wei Chen; Bryant C Yung; Zhiyong Qian; Xiaoyuan Chen
Journal: Adv Drug Deliv Rev Date: 2018-01-31 Impact factor: 15.470

Review 8. Advances in bioresponsive closed-loop drug delivery systems.

Authors: Jicheng Yu; Yuqi Zhang; Junjie Yan; Anna R Kahkoska; Zhen Gu
Journal: Int J Pharm Date: 2017-11-27 Impact factor: 5.875

Review 9. Engineering precision biomaterials for personalized medicine.

Authors: Brian A Aguado; Joseph C Grim; Adrianne M Rosales; Jana J Watson-Capps; Kristi S Anseth
Journal: Sci Transl Med Date: 2018-01-17 Impact factor: 17.956

10. Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans.

Authors: Miriam de J Velásquez-Hernández; Efwita Astria; Sarah Winkler; Weibin Liang; Helmar Wiltsche; Arpita Poddar; Ravi Shukla; Glenn Prestwich; John Paderi; Pablo Salcedo-Abraira; Heinz Amenitsch; Patricia Horcajada; Christian J Doonan; Paolo Falcaro
Journal: Chem Sci Date: 2020-07-14 Impact factor: 9.825