Literature DB >> 27884223

Local Renin Angiotensin Aldosterone Systems and Cardiovascular Diseases.

Walmor C De Mello1.   

Abstract

The presence of local renin angiotensin aldosterone systems (RAAS) in the cardiovascular and renal tissues and their influence in cardiovascular and renal diseases are described. The fundamental role of ACE/Ang II/AT1 receptor axis activation as well the counterregulatory role of ACE2/Ang (1-7)/Mas receptor activation on cardiovascular and renal physiology and pathology are emphasized. The presence of a local RAS and its influence on hypertension is discussed, and finally, the hypothesis that epigenetic factors change the RAAS in utero and induce the expression of renin or Ang II inside the cells of the cardiovascular system is presented. Copyright Â
© 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cardiovascular diseases; Expression; Internalization; Local renin angiotensin

Mesh：

Substances：

Year:  2017        PMID： 27884223     DOI： 10.1016/j.mcna.2016.08.017

Source DB:  PubMed          Journal:  Med Clin North Am        ISSN： 0025-7125            Impact factor:   5.456


  16 in total

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Journal:  Int J Cardiol       Date:  2018-04-21       Impact factor: 4.164

3.  Losartan counteracts the effects of cardiomyocyte swelling on glucose uptake and insulin receptor substrate-1 levels.

Authors:  Yamil Gerena; Janice Griselle Lozada; Bryan Jael Collazo; Jarold Méndez-Álvarez; Jennifer Méndez-Estrada; Walmor C De Mello
Journal:  Peptides       Date:  2017-09-07       Impact factor: 3.750

Review 4.  Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism.

Authors:  Sarah A Sapouckey; Guorui Deng; Curt D Sigmund; Justin L Grobe
Journal:  Physiol Genomics       Date:  2017-10-06       Impact factor: 3.107

Review 5.  Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms.

Authors:  Worapaka Manosroi; Gordon H Williams
Journal:  Endocr Rev       Date:  2019-06-01       Impact factor: 19.871

Review 6.  Invited review: hypertension and atrial fibrillation: epidemiology, pathophysiology, and implications for management.

Authors:  Jakub Gumprecht; Magdalena Domek; Gregory Y H Lip; Alena Shantsila
Journal:  J Hum Hypertens       Date:  2019-11-05       Impact factor: 3.012

7.  Angiotensin II type 1 receptor mediates pulmonary hypertension and right ventricular remodeling induced by inhaled nicotine.

Authors:  Nicholas D Fried; Tamara M Morris; Anna Whitehead; Eric Lazartigues; Xinping Yue; Jason D Gardner
Journal:  Am J Physiol Heart Circ Physiol       Date:  2021-02-12       Impact factor: 4.733

8.  Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women.

Authors:  Robert Y L Zee; Alicia Rivera; Yaritza Inostroza; Paul M Ridker; Daniel I Chasman; Jose R Romero
Journal:  Int J Genomics       Date:  2018-04-19       Impact factor: 2.326

9.  Two Sulfur Glycoside Compounds Isolated from Lepidium apetalum Willd Protect NRK52e Cells against Hypertonic-Induced Adhesion and Inflammation by Suppressing the MAPK Signaling Pathway and RAAS.

Authors:  Peipei Yuan; Xiaoke Zheng; Meng Li; Yingying Ke; Yang Fu; Qi Zhang; Xiaolan Wang; Weisheng Feng
Journal:  Molecules       Date:  2017-11-12       Impact factor: 4.411

10.  Physiological cyclic stretch up-regulates angiotensin-converting enzyme 2 expression to reduce proliferation and migration of vascular smooth muscle cells.

Authors:  Jiantao Song; Haiyan Qu; Bo Hu; Chenglong Bi; Mengmeng Li; Lin Wang; Xiaozhen Huang; Mei Zhang
Journal:  Biosci Rep       Date:  2020-06-26       Impact factor: 3.840
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