Asma Sriha Belguith1, Afifa Koubaa Abdelkafi2, Sana El Mhamdi3, Manel Ben Fredj4, Hela Abroug5, Arwa Ben Salah6, Inès Bouanene7, Fahima Hassine8, Amal Amara9, Sana Bhiri10, Abdelkarim Derbel11, Habib Gamra12, Faouzi Maatouk13, Mohamed Soussi Soltani14. 1. Department of Epidemiology and Preventive Medicine, University Hospital of Monastir, Tunisia. Electronic address: belguith_asma@yahoo.fr. 2. Stah Jabeur Primary Health Center, Monastir Health Group, Monastir, Tunisia. Electronic address: abdelkafiafifa@yahoo.fr. 3. Department of Epidemiology and Preventive Medicine, University Hospital of Monastir, Tunisia. Electronic address: sanaelmhamdi@gmail.com. 4. Department of Epidemiology and Preventive Medicine, University Hospital of Monastir, Tunisia. Electronic address: manel-ben-fredj@hotmail.fr. 5. Department of Epidemiology and Preventive Medicine, University Hospital of Monastir, Tunisia. Electronic address: hela-abr@hotmail.com. 6. Department of Epidemiology and Preventive Medicine, University Hospital of Monastir, Tunisia. Electronic address: bensalah.arwa@yahoo.fr. 7. Department of Epidemiology and Preventive Medicine, University Hospital of Monastir, Tunisia. Electronic address: bouaneneines@gmail.com. 8. Sayada Primary Health Center, Monastir Health Group, Monastir, Tunisia. Electronic address: hassine_fahima@yahoo.fr. 9. Department of Epidemiology and Preventive Medicine, University Hospital of Monastir, Tunisia. Electronic address: amel.amara1@yahoo.fr. 10. Department of Epidemiology and Preventive Medicine, University Hospital of Monastir, Tunisia. Electronic address: bhirisana@yahoo.com. 11. Primary Health Center, Sfax Health Group, Sfax, Tunisia. Electronic address: drderbelabdelkarim@yahoo.fr. 12. Department of Cardiology A, University Hospital of Monastir, Monastir, Tunisia. Electronic address: hgamra@rns.tn. 13. Department of Cardiology B, University Hospital of Monastir, Monastir, Tunisia. Electronic address: mf.maatouk@rns.tn. 14. Department of Epidemiology and Preventive Medicine, University Hospital of Monastir, Tunisia. Electronic address: mohamed.soltani@rns.tn.
Abstract
BACKGROUND: The penicillin therapy of β hemolytic streptococcal pharyngitis has aided in the decrease of rheumatic heart disease (RHD) in developing countries. Tunisia is an endemic area, however, and incidence of RHD is weakly documented. We aimed at establishing the standardized incidence rate (SIR) of RHD in Monastir governorate and at determining RHD prevalence among hospitalized patients in two cardiology departments. METHODS: From the regional register of Monastir Hospital morbidity, we have selected newly diagnosed patients with RHD, residents of Monastir, and hospitalized to the 2 cardiology departments between 2000 and 2013 (2001 not included). FINDINGS: We studied 676 newly admitted patients. We estimate 1060 to be the number of new annual RHD cases in Tunisia. The SIR per 105 person-years was 10.97, being 9.3 in men and 19.1 in women, respectively. We have notified a negative trend of crude incidence rate/105 Inhabitants (Inh) (CIR) (r=-0.23, p<10-3), and a strong positive correlation between age and CIR/105 Inh (r=0.989, p<10-4). RHD lethality was 1%. We have registered 728 hospitalizations for RHD, representing 2.5% of all cardiology hospitalizations [95% CI: 2.3-2.7%], with a prevalence for 13.3% for women aged 15-29years. The median hospital stay was 9days (IQR: 5-15). CONCLUSION: Our results confirm the RHD incidence decrease, consistent with epidemiological transition in Tunisia. We have also emphasized on the close trend of RHD with age and the predominance of RHD among women especially at the procreation age.
BACKGROUND: The penicillin therapy of β hemolytic streptococcal pharyngitis has aided in the decrease of rheumatic heart disease (RHD) in developing countries. Tunisia is an endemic area, however, and incidence of RHD is weakly documented. We aimed at establishing the standardized incidence rate (SIR) of RHD in Monastir governorate and at determining RHD prevalence among hospitalized patients in two cardiology departments. METHODS: From the regional register of Monastir Hospital morbidity, we have selected newly diagnosed patients with RHD, residents of Monastir, and hospitalized to the 2 cardiology departments between 2000 and 2013 (2001 not included). FINDINGS: We studied 676 newly admitted patients. We estimate 1060 to be the number of new annual RHD cases in Tunisia. The SIR per 105 person-years was 10.97, being 9.3 in men and 19.1 in women, respectively. We have notified a negative trend of crude incidence rate/105 Inhabitants (Inh) (CIR) (r=-0.23, p<10-3), and a strong positive correlation between age and CIR/105 Inh (r=0.989, p<10-4). RHD lethality was 1%. We have registered 728 hospitalizations for RHD, representing 2.5% of all cardiology hospitalizations [95% CI: 2.3-2.7%], with a prevalence for 13.3% for women aged 15-29years. The median hospital stay was 9days (IQR: 5-15). CONCLUSION: Our results confirm the RHD incidence decrease, consistent with epidemiological transition in Tunisia. We have also emphasized on the close trend of RHD with age and the predominance of RHD among women especially at the procreation age.