| Literature DB >> 27882177 |
Jinyan Zhong1, Xiaoying Chen2, Nan Wu1, Caijie Shen3, Hanbin Cui1, Weiping Du1, Zhaoxia Zhang1, Mingjun Feng1, Junsong Liu1, Shaoyi Lin1, Lulu Zhang1, Jian Wang1, Xiaomin Chen1, Shiwei Duan2.
Abstract
Catechol-O-methyltransferase (COMT) gene variation is known to be associated with the risk of acute coronary events. The purpose of the present study was to investigate the contribution of COMT promoter methylation towards the risk of coronary heart disease (CHD). COMT methylation was evaluated in 48 CHD cases and 48 well-matched non-CHD controls using bisulfite pyrosequencing technology. The results demonstrated that CHD cases had a significantly lower level of methylation at COMT CpG3 sites compared with the controls (33.77±5.71 vs. 36.42±5.00%; P=0.018). Further analysis, according to gender, showed that CpG3 methylation was associated with CHD in males (P=0.038) but not in females (P=0.253), suggesting that there is a gender disparity in the association between COMT methylation and CHD. In conclusion, it was determined that COMT CpG3 hypomethylation is associated with an increased risk of CHD in males.Entities:
Keywords: DNA methylation; catechol-O-methyltransferase; coronary heart disease; male; promoter
Year: 2016 PMID： 27882177 PMCID： PMC5103840 DOI： 10.3892/etm.2016.3757
Source DB: PubMed Journal: Exp Ther Med ISSN： 1792-0981 Impact factor: 2.447