Literature DB >> 27881067

Emerging Nanocarriers-based Approaches to Diagnose and Red uce Vascular Inflammation in Atherosclerosis.

Manuela Calin1, Ileana Manduteanu.   

Abstract

Exploitation of nanotechnology advances in the cardiovascular medicine has led to new approaches for the diagnosis and therapy of vascular inflammation associated to cardiovascular diseases. Innovative nanoparticles targeted to the main players in the arterial wall inflammation in atherosclerosis (i.e. inflammatory molecules, immune or resident cells) have been already developed to diagnose and/or reduce excessive vascular inflammation and is eagerly awaited that promising preclinical and early clinical results to boost the approval of the first nanocarrier in this field. This review discusses the challenges and the steps undertaken so far to produce powerful multifunctional nanoparticles capable of raising new scenarios for future precision medicine in atherosclerosis. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Atherosclerosis; diagnosis; inflammation; nanoparticles; nanotherapy; vascular wall

Mesh:

Substances:

Year:  2017        PMID: 27881067     DOI: 10.2174/0929867324666161123091627

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN: 0929-8673            Impact factor:   4.530


  8 in total

1.  Synthetic lipoproteins based on apolipoprotein E coupled to fullerenol have anti-atherosclerotic properties.

Authors:  Irina Florina Tudorache; Violeta Georgeta Bivol; Madalina Dumitrescu; Ioana Madalina Fenyo; Maya Simionescu; Anca Violeta Gafencu
Journal:  Pharmacol Rep       Date:  2022-07-05       Impact factor: 3.919

2.  Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of Gi-protein inhibitor.

Authors:  Monica Madalina Tucureanu; Daniela Rebleanu; Cristina Ana Constantinescu; Mariana Deleanu; Geanina Voicu; Elena Butoi; Manuela Calin; Ileana Manduteanu
Journal:  Int J Nanomedicine       Date:  2017-12-20

3.  Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting.

Authors:  Yaping He; Jian Xu; Xian Sun; Xiaohong Ren; Abi Maharjan; Peter York; Yong Su; Haiyan Li; Jiwen Zhang
Journal:  Theranostics       Date:  2019-04-13       Impact factor: 11.556

Review 4.  Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis.

Authors:  Artur Y Prilepskii; Nikita S Serov; Daniil V Kladko; Vladimir V Vinogradov
Journal:  Pharmaceutics       Date:  2020-11-05       Impact factor: 6.321

5.  Evaluation of VCAM-1 Targeted Naringenin/Indocyanine Green-Loaded Lipid Nanoemulsions as Theranostic Nanoplatforms in Inflammation.

Authors:  Elena Valeria Fuior; Cristina Ana Mocanu; Mariana Deleanu; Geanina Voicu; Maria Anghelache; Daniela Rebleanu; Maya Simionescu; Manuela Calin
Journal:  Pharmaceutics       Date:  2020-11-09       Impact factor: 6.321

6.  Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe.

Authors:  Simona-Adriana Manea; Mihaela-Loredana Vlad; Daniela Rebleanu; Alexandra-Gela Lazar; Ioana Madalina Fenyo; Manuela Calin; Maya Simionescu; Adrian Manea
Journal:  Oxid Med Cell Longev       Date:  2021-03-09       Impact factor: 6.543

7.  VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment.

Authors:  Geanina Voicu; Daniela Rebleanu; Cristina Ana Mocanu; Gabriela Tanko; Ionel Droc; Cristina Mariana Uritu; Mariana Pinteala; Ileana Manduteanu; Maya Simionescu; Manuela Calin
Journal:  Int J Mol Sci       Date:  2022-03-30       Impact factor: 5.923

Review 8.  Biomaterial-Driven Immunomodulation: Cell Biology-Based Strategies to Mitigate Severe Inflammation and Sepsis.

Authors:  Jackline Joy Martín Lasola; Henry Kamdem; Michael W McDaniel; Ryan M Pearson
Journal:  Front Immunol       Date:  2020-08-04       Impact factor: 7.561

  8 in total

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