Dan Li1,2, Peiyu Huang3, Yufeng Zang4, Yuting Lou1, Zhidong Cen1, Quanquan Gu3, Min Xuan3, Fei Xie1, Zhiyuan Ouyang1, Bo Wang1, Minming Zhang3, Wei Luo1. 1. Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 2. Department of Neurology, First People's Hospital of Nantong, Nantong, China. 3. Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 4. Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China.
Abstract
PURPOSE: To investigate the differences in spontaneous brain activity between Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD), PD patients without RBD, and normal controls, which may shed new light on the neural mechanism of RBD. MATERIALS AND METHODS: Eighteen PD patients with RBD, 16 patients without RBD, and 19 age- and gender-matched normal controls underwent clinical assessment and functional magnetic resonance imaging (fMRI) with a 3.0T scanner. Resting-state fMRI scans were collected using an echo planar imaging sequence. Amplitude of low-frequency fluctuations (ALFF) were calculated to measure spontaneous brain activity in each subject. RESULTS: Compared with PD patients without RBD, patients with RBD exhibited significantly decreased ALFF values (P < 0.001, cluster level) in primary motor cortex extending to premotor cortex. Compared with normal controls, PD patients exhibited decreased ALFF values (P < 0.001, cluster level) in caudate and putamen (P < 0.001, cluster level), and increased ALFF values (P = 0.03, cluster level) in prefrontal cortex. CONCLUSION: The altered spontaneous brain activity in motor cortex may contribute to the pathogenesis of RBD in PD patients, which further supports the idea that the pathophysiology of RBD involves not only midbrain dysfunction but also cerebral cortex abnormalities. Our findings provide additional insight into the neural mechanism of RBD and may drive future research to develop better treatment. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2017;46:697-703.
PURPOSE: To investigate the differences in spontaneous brain activity between Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD), PDpatients without RBD, and normal controls, which may shed new light on the neural mechanism of RBD. MATERIALS AND METHODS: Eighteen PDpatients with RBD, 16 patients without RBD, and 19 age- and gender-matched normal controls underwent clinical assessment and functional magnetic resonance imaging (fMRI) with a 3.0T scanner. Resting-state fMRI scans were collected using an echo planar imaging sequence. Amplitude of low-frequency fluctuations (ALFF) were calculated to measure spontaneous brain activity in each subject. RESULTS: Compared with PDpatients without RBD, patients with RBD exhibited significantly decreased ALFF values (P < 0.001, cluster level) in primary motor cortex extending to premotor cortex. Compared with normal controls, PDpatients exhibited decreased ALFF values (P < 0.001, cluster level) in caudate and putamen (P < 0.001, cluster level), and increased ALFF values (P = 0.03, cluster level) in prefrontal cortex. CONCLUSION: The altered spontaneous brain activity in motor cortex may contribute to the pathogenesis of RBD in PDpatients, which further supports the idea that the pathophysiology of RBD involves not only midbrain dysfunction but also cerebral cortex abnormalities. Our findings provide additional insight into the neural mechanism of RBD and may drive future research to develop better treatment. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2017;46:697-703.
Authors: Xu Jiang; Zhuang Wu; Min Zhong; Bo Shen; Jun Zhu; Yang Pan; Jun Yan; Wenbin Zhang; Pingyi Xu; Chaoyong Xiao; Li Zhang Journal: Parkinsons Dis Date: 2021-02-22
Authors: Eva M Müller-Oehring; Jui-Yang Hong; Rachel L Hughes; Dongjin Kwon; Helen M Brontë-Stewart; Kathleen L Poston; Tilman Schulte Journal: J Neuroimmune Pharmacol Date: 2020-04-14 Impact factor: 7.285