| Literature DB >> 27879212 |
Carlota Pires1, Benjamin Schmid2, Carina Petræus1, Anna Poon1, Natakarn Nimsanor3, Troels T Nielsen4, Gunhild Waldemar4, Lena E Hjermind4, Jørgen E Nielsen4, Poul Hyttel1, Kristine K Freude5.
Abstract
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease causing neural cell degeneration and brain atrophy and is considered to be the most common form of dementia. We previously generated an induced pluripotent stem cell (iPSC) line from an AD patient carrying an A79V mutation in PSEN1 as an in vitro disease model. Here we generated a gene-corrected version from this hiPSC line by substituting the point mutation with the wild-type sequence. The reported A79V-GC-iPSCs line is a very useful resource in combination with the A79V-iPSC line in order to study pathological cellular phenotypes related to this particular mutation.Entities:
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Year: 2016 PMID： 27879212 DOI： 10.1016/j.scr.2016.08.002
Source DB: PubMed Journal: Stem Cell Res ISSN： 1873-5061 Impact factor: 2.020