Emad Abdallah1, Samya El-Shishtawy2, Nevine Sherif2, Ahmed Ali3, Omnia El-Bendary4. 1. Department of Nephrology, Theodor Bilharz Research Institute, El-Nile St. Waraq El-Hadar, P.O. Box 30, Imbaba, Giza, 12411, Egypt. drabdallah96@gmail.com. 2. Department of Nephrology, Theodor Bilharz Research Institute, El-Nile St. Waraq El-Hadar, P.O. Box 30, Imbaba, Giza, 12411, Egypt. 3. Department of Intensive Care Unit, Theodor Bilharz Research Institute, Cairo, Egypt. 4. Department of Clinical Chemistry, Theodor Bilharz Research Institute, Cairo, Egypt.
Abstract
PURPOSE: Paraoxonase-1 (PON-1) is a high-density lipoprotein-associated (HDL) enzyme, which has been shown to reduce susceptibility to low-density lipoprotein (LDL) peroxidation. Epicardial adipose tissue (EAT) is a marker of atherosclerosis. The aim of this study was to determine the relationship between PON-1 activity and EAT in hemodialysis (HD) patients. METHODS: This is a cross-sectional study conducted on 72 (43 males) HD patients with end-stage renal disease. Serum levels for lipid profiles, C-reactive protein, calcium, phosphate, and parathyroid hormone were measured. PON-1 activity was also measured and compared to the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol. Echocardiography was used to measure EAT thickness (EATT). The correlation between PON-1 and EATT was assessed, while independent predictors of EATT in HD patients were similarly assessed using multivariate regression analysis. RESULTS: There was a significant low mean value of PON-1 activity in HD patients compared with the control group (82.1 ± 31.6 vs. 164.3 ± 61.5 U/l, p = 0.0001) and significant high mean value of EATT in HD patients, compared with controls (6.2 ± 1.7 vs. 3.9 ± 1.1 mm, p = 0.0001). In addition, there was a significant negative correlation between PON-1 activity and EATT (r = -0.484, p = 0.0001) and a significant positive correlation between PON-1 activity and HDL-C (r = 0.417, p = 0.0003). PON-1, total cholesterol, triglycerides, LDL, HDL, age, and body mass index were found to be independent predictors of EATT. CONCLUSION: Our study demonstrated that PON-1 activity was significantly lower in HD patients compared with healthy controls and that PON-1 activity was inversely correlated with EATT in this population.
PURPOSE:Paraoxonase-1 (PON-1) is a high-density lipoprotein-associated (HDL) enzyme, which has been shown to reduce susceptibility to low-density lipoprotein (LDL) peroxidation. Epicardial adipose tissue (EAT) is a marker of atherosclerosis. The aim of this study was to determine the relationship between PON-1 activity and EAT in hemodialysis (HD) patients. METHODS: This is a cross-sectional study conducted on 72 (43 males) HDpatients with end-stage renal disease. Serum levels for lipid profiles, C-reactive protein, calcium, phosphate, and parathyroid hormone were measured. PON-1 activity was also measured and compared to the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol. Echocardiography was used to measure EAT thickness (EATT). The correlation between PON-1 and EATT was assessed, while independent predictors of EATT in HDpatients were similarly assessed using multivariate regression analysis. RESULTS: There was a significant low mean value of PON-1 activity in HDpatients compared with the control group (82.1 ± 31.6 vs. 164.3 ± 61.5 U/l, p = 0.0001) and significant high mean value of EATT in HDpatients, compared with controls (6.2 ± 1.7 vs. 3.9 ± 1.1 mm, p = 0.0001). In addition, there was a significant negative correlation between PON-1 activity and EATT (r = -0.484, p = 0.0001) and a significant positive correlation between PON-1 activity and HDL-C (r = 0.417, p = 0.0003). PON-1, total cholesterol, triglycerides, LDL, HDL, age, and body mass index were found to be independent predictors of EATT. CONCLUSION: Our study demonstrated that PON-1 activity was significantly lower in HDpatients compared with healthy controls and that PON-1 activity was inversely correlated with EATT in this population.
Authors: R Scott Rector; Shana O Warner; Ying Liu; Pamela S Hinton; Grace Y Sun; Richard H Cox; Craig S Stump; M Harold Laughlin; Kevin C Dellsperger; Tom R Thomas Journal: Am J Physiol Endocrinol Metab Date: 2007-05-01 Impact factor: 4.310
Authors: T F Dantoine; J Debord; J P Charmes; L Merle; P Marquet; G Lachatre; C Leroux-Robert Journal: J Am Soc Nephrol Date: 1998-11 Impact factor: 10.121
Authors: Zülfükar Yilmaz; Hasan İnce; Emre Aydin; Yasar Yildirim; Fatma Yilmaz Aydin; Enver Yüksel; Aziz Karabulut; Lezgin Dursun; Ali Kemal Kadiroğlu; Mehmet Emin Yilmaz Journal: Med Sci Monit Date: 2020-02-07