| Literature DB >> 27878717 |
T G Razina1, E P Zueva2, A V Ulrich2, O Yu Rybalkina2,3, A V Chaikovskii2, N V Isaikina4, G I Kalinkina4, V V Zhdanov2, G N Zyuz'kov2,3.
Abstract
The effects of Fructus Sorbi aucupariae extract, originally saturated with anthocyans, on the development of Lewis lung carcinoma and B-16 melanoma in C57Bl/6 mice and the efficiency of cyclophosphamide treatment were studied. Antitumor activity of the extract and potentiation of the antimetastatic activity of the cytostatic were demonstrated. Studies on melanoma B-16 model revealed an increase in the counts of stromal progenitor cells in the tumor node and their accelerated maturation after treatment with the extract. No effects towards the tumor stem and committed cells were detected.Entities:
Keywords: B-16 melanoma; Fructus Sorbi aucupariae; Lewis lung carcinoma; anthocyans; tumor stem cells
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Year: 2016 PMID： 27878717 DOI： 10.1007/s10517-016-3554-4
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804